Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report
We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2019/7940291 |
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| author | Sangeeta Mutnuri Hania Kassem John Badalamenti You-Wen Qian Christopher Marquez Marjan Afrouzian |
| author_facet | Sangeeta Mutnuri Hania Kassem John Badalamenti You-Wen Qian Christopher Marquez Marjan Afrouzian |
| author_sort | Sangeeta Mutnuri |
| collection | DOAJ |
| description | We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Our case raises awareness regarding possibility of monoclonality in the renal biopsy of HCV-infected patients and exemplifies the crucial role the renal biopsy plays in detecting lymphoid malignancies where clinical features are ambiguous. |
| format | Article |
| id | doaj-art-b6a91f3ce1734da6a3dc526ef3976e81 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-b6a91f3ce1734da6a3dc526ef3976e812025-02-03T05:43:53ZengWileyCase Reports in Nephrology2090-66412090-665X2019-01-01201910.1155/2019/79402917940291Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case ReportSangeeta Mutnuri0Hania Kassem1John Badalamenti2You-Wen Qian3Christopher Marquez4Marjan Afrouzian5Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USADepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USADepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USADepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USADepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USAWe report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Our case raises awareness regarding possibility of monoclonality in the renal biopsy of HCV-infected patients and exemplifies the crucial role the renal biopsy plays in detecting lymphoid malignancies where clinical features are ambiguous.http://dx.doi.org/10.1155/2019/7940291 |
| spellingShingle | Sangeeta Mutnuri Hania Kassem John Badalamenti You-Wen Qian Christopher Marquez Marjan Afrouzian Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report Case Reports in Nephrology |
| title | Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report |
| title_full | Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report |
| title_fullStr | Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report |
| title_full_unstemmed | Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report |
| title_short | Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report |
| title_sort | lymphoma associated monoclonal cryoglobulinemic glomerulonephritis and relationship with hepatitis c virus infection a case report |
| url | http://dx.doi.org/10.1155/2019/7940291 |
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