The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial

Abstract Background Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents. Compelling evidence has shown that such a population has a greater risk of cardiovascular events as well as mortality. Although minera...

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Bibliographic Details
Main Authors: Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Trials
Subjects:
Online Access:https://doi.org/10.1186/s13063-025-08719-8
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