Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy
Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and th...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/452795 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552093738598400 |
|---|---|
| author | Panagiotis J. Vlachostergios Foteini Karasavvidou Grigorios Kakkas George Moutzouris Anna Patrikidou Ioannis A. Voutsadakis Danai D. Daliani Elias Zintzaras Michael D. Melekos Christos N. Papandreou |
| author_facet | Panagiotis J. Vlachostergios Foteini Karasavvidou Grigorios Kakkas George Moutzouris Anna Patrikidou Ioannis A. Voutsadakis Danai D. Daliani Elias Zintzaras Michael D. Melekos Christos N. Papandreou |
| author_sort | Panagiotis J. Vlachostergios |
| collection | DOAJ |
| description | Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations. Membranous expression of NEP (P<0.001), cytoplasmic ET-1 (P=0.002), and cytoplasmic NFκB (P<0.001) were correlated with time to PSA relapse. NEP was associated with ET-1 (P<0.001) and NFκB (P<0.001). ET-1 was also correlated with NFκB (P<0.001). NEP expression (P=0.017), pT stage (P=0.013), and SMs (P=0.036) were independent predictors of time to PSA recurrence.
Conclusions. There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations. |
| format | Article |
| id | doaj-art-b646f1f4afa34ee8965f58c43385ab5c |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-b646f1f4afa34ee8965f58c43385ab5c2025-02-03T05:59:36ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/452795452795Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical ProstatectomyPanagiotis J. Vlachostergios0Foteini Karasavvidou1Grigorios Kakkas2George Moutzouris3Anna Patrikidou4Ioannis A. Voutsadakis5Danai D. Daliani6Elias Zintzaras7Michael D. Melekos8Christos N. Papandreou9Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceDepartment of Pathology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceDepartment of Urology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceDepartment of Urology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceDepartment of Medicine, Institut Gustave Roussy, 94805 Villejuif, FranceCentre Pluridisciplinaire d'Oncologie, Centre Hospitalier Universitaire Vaudois, 1101Lausanne, SwitzerlandDepartment of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceDepartment of Biomathematics, University of Thessaly School of Medicine, 41222 Larissa, GreeceDepartment of Urology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceDepartment of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, GreeceObjective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations. Membranous expression of NEP (P<0.001), cytoplasmic ET-1 (P=0.002), and cytoplasmic NFκB (P<0.001) were correlated with time to PSA relapse. NEP was associated with ET-1 (P<0.001) and NFκB (P<0.001). ET-1 was also correlated with NFκB (P<0.001). NEP expression (P=0.017), pT stage (P=0.013), and SMs (P=0.036) were independent predictors of time to PSA recurrence. Conclusions. There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.http://dx.doi.org/10.1155/2012/452795 |
| spellingShingle | Panagiotis J. Vlachostergios Foteini Karasavvidou Grigorios Kakkas George Moutzouris Anna Patrikidou Ioannis A. Voutsadakis Danai D. Daliani Elias Zintzaras Michael D. Melekos Christos N. Papandreou Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy Prostate Cancer |
| title | Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy |
| title_full | Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy |
| title_fullStr | Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy |
| title_full_unstemmed | Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy |
| title_short | Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy |
| title_sort | expression of neutral endopeptidase endothelin 1 and nuclear factor kappa b in prostate cancer interrelations and associations with prostate specific antigen recurrence after radical prostatectomy |
| url | http://dx.doi.org/10.1155/2012/452795 |
| work_keys_str_mv | AT panagiotisjvlachostergios expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT foteinikarasavvidou expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT grigorioskakkas expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT georgemoutzouris expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT annapatrikidou expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT ioannisavoutsadakis expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT danaiddaliani expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT eliaszintzaras expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT michaeldmelekos expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy AT christosnpapandreou expressionofneutralendopeptidaseendothelin1andnuclearfactorkappabinprostatecancerinterrelationsandassociationswithprostatespecificantigenrecurrenceafterradicalprostatectomy |