Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically relevant asexual blood stages, many aspects of malaria...

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Bibliographic Details
Main Authors: Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012360
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https://doi.org/10.1371/journal.ppat.1012360

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