Poly-(L-homoarginine) for the non-invasive treatment of endophthalmitis
Bacterial endophthalmitis (BE) is a severe eye infection that often leads to vision loss or blindness. The conventional therapeutic approach entails the administration of intravitreal antibiotic injections, a procedure that is associated with significant discomfort for the patient. Here, we present...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425005010 |
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| Summary: | Bacterial endophthalmitis (BE) is a severe eye infection that often leads to vision loss or blindness. The conventional therapeutic approach entails the administration of intravitreal antibiotic injections, a procedure that is associated with significant discomfort for the patient. Here, we present a kind of poly-(L-homoarginine) (C6PLL10-Gua) as a non-invasive alternative for effectively eliminating bacteria in endophthalmitis. The synthesized C6PLL10-Gua effectively kills various bacteria by disrupting cell membranes, without causing bacteria resistance over 14 generations. More importantly, C6PLL10-Gua demonstrated significant tissue permeability both in vivo and in vitro. This kind of C6PLL10-Gua eye drops were capable of effectively traversing the ocular barrier to access the posterior segment of the eye. After being instilled into the conjunctival sac, C6PLL10-Gua enabled rapid (<30 min) and prolonged (>24 h) distribution in the retina via a noncorneal pathway. Furthermore, in a MRSA induced endophthalmitis rat model, topical instillation of C6PLL10-Gua showed significant therapeutic effect, which presenting a promising non-invasive therapeutic approach for managing endophthalmitis. |
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| ISSN: | 2590-0064 |