Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with the syndrome of cognitive and functional decline. Pharmacotherapy has always been in a dominant position for the treatment of AD. However, in most cases, drug therapy is accompanied with clinical delays when older adults have s...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/9234105 |
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| _version_ | 1832563588296867840 |
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| author | Meng Ying Cui Yang Lin Ji Yao Sheng Xuewen Zhang Ran Ji Cui |
| author_facet | Meng Ying Cui Yang Lin Ji Yao Sheng Xuewen Zhang Ran Ji Cui |
| author_sort | Meng Ying Cui |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disease with the syndrome of cognitive and functional decline. Pharmacotherapy has always been in a dominant position for the treatment of AD. However, in most cases, drug therapy is accompanied with clinical delays when older adults have suffered from cognitive decline in episodic memory, working memory, and executive function. On the other hand, accumulating evidence suggests that exercise intervention may ameliorate the progression of cognitive impairment in aging ones while the standard strategy is lacking based on different levels of cognitive decline especially in mild cognitive impairment (MCI) and AD. MCI is the preclinical stage of AD in which neurodegeneration may be reversed via neuroplasticity. Therefore, taking exercise intervention in the early stage of MCI and healthy aging at the risk of AD could slow down the process of cognitive impairment and provide a promising cost-effective nonpharmacological therapy to dementia. |
| format | Article |
| id | doaj-art-b5f23cea879743a7b7dd8a6e12cf7001 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b5f23cea879743a7b7dd8a6e12cf70012025-02-03T01:13:11ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/92341059234105Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s DiseaseMeng Ying Cui0Yang Lin1Ji Yao Sheng2Xuewen Zhang3Ran Ji Cui4Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaAlzheimer’s disease (AD) is a progressive neurodegenerative disease with the syndrome of cognitive and functional decline. Pharmacotherapy has always been in a dominant position for the treatment of AD. However, in most cases, drug therapy is accompanied with clinical delays when older adults have suffered from cognitive decline in episodic memory, working memory, and executive function. On the other hand, accumulating evidence suggests that exercise intervention may ameliorate the progression of cognitive impairment in aging ones while the standard strategy is lacking based on different levels of cognitive decline especially in mild cognitive impairment (MCI) and AD. MCI is the preclinical stage of AD in which neurodegeneration may be reversed via neuroplasticity. Therefore, taking exercise intervention in the early stage of MCI and healthy aging at the risk of AD could slow down the process of cognitive impairment and provide a promising cost-effective nonpharmacological therapy to dementia.http://dx.doi.org/10.1155/2018/9234105 |
| spellingShingle | Meng Ying Cui Yang Lin Ji Yao Sheng Xuewen Zhang Ran Ji Cui Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease Neural Plasticity |
| title | Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease |
| title_full | Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease |
| title_fullStr | Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease |
| title_full_unstemmed | Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease |
| title_short | Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease |
| title_sort | exercise intervention associated with cognitive improvement in alzheimer s disease |
| url | http://dx.doi.org/10.1155/2018/9234105 |
| work_keys_str_mv | AT mengyingcui exerciseinterventionassociatedwithcognitiveimprovementinalzheimersdisease AT yanglin exerciseinterventionassociatedwithcognitiveimprovementinalzheimersdisease AT jiyaosheng exerciseinterventionassociatedwithcognitiveimprovementinalzheimersdisease AT xuewenzhang exerciseinterventionassociatedwithcognitiveimprovementinalzheimersdisease AT ranjicui exerciseinterventionassociatedwithcognitiveimprovementinalzheimersdisease |