A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements

Abstract It has been challenging to test how proteins acquire specific metals in cells. The speciation of metalation is thought to depend on the preferences of proteins for different metals competing at intracellular metal-availabilities. This implies mis-metalation may occur if proteins become mis-...

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Bibliographic Details
Main Authors: Sophie E. Clough, Tessa R. Young, Emma Tarrant, Andrew J. P. Scott, Peter T. Chivers, Arthur Glasfeld, Nigel J. Robinson
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56199-w
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