Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair
Abstract This study examines the biocompatibility, osteogenic potential, and effectiveness of polyether ether ketone (PEEK) composites for treating osteonecrosis, seeking to establish a theoretical basis for clinical application. A range of PEEK composite materials, including sulfonated polyether et...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86965-1 |
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| author | Yi Sun Jingyun Liu Kaijia Chen Nannan Zhong Chengpeng He Xinming Luan Xiaobei Zang Jianbo Sun Ning Cao Wenbo Wang Qiang Ren |
| author_facet | Yi Sun Jingyun Liu Kaijia Chen Nannan Zhong Chengpeng He Xinming Luan Xiaobei Zang Jianbo Sun Ning Cao Wenbo Wang Qiang Ren |
| author_sort | Yi Sun |
| collection | DOAJ |
| description | Abstract This study examines the biocompatibility, osteogenic potential, and effectiveness of polyether ether ketone (PEEK) composites for treating osteonecrosis, seeking to establish a theoretical basis for clinical application. A range of PEEK composite materials, including sulfonated polyether ether ketone (SPEEK), polydopamine-sulfonated polyether ether ketone (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-BFP), and vascular endothelial growth factor-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-VEGF), were constructed by concentrated sulfuric acid sulfonation, polydopamine modification and grafting of bioactive factors. The experiments involved adult male New Zealand rabbits aged 24–28 weeks and weighing 2.6–4 kg. The SPEEK-PDA-BFP possesses the smallest water contact angle, indicating the highest hydrophilicity, with its surface characterized by a rich density of clustered BFP particles. The SPEEK-PDA-BFP exhibits superior adhesion, proliferation, and differentiation capabilities, along with pronounced bacteriostatic effects, which are attributed to its dense particle clusters. The SPEEK-PDA-BFP facilitates the formation of regular and dense bone trabeculae. Comparative study on treating osteonecrosis with SPEEK-PDA-VEGF and SPEEK-PDA-BFP highlighted the superior formation of mature bone trabeculae and angiogenic protein CD31 around SPEEK-PDA-VEGF. The PEEK composite materials have good biocompatibility, osteogenic activity and bone repair activity. In particular, SPEEK-PDA-VEGF composite materials have the best effect on bone repair. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b5ca5b0423e54da3a85dacb589c3d7082025-02-02T12:22:39ZengNature PortfolioScientific Reports2045-23222025-01-0115111510.1038/s41598-025-86965-1Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repairYi Sun0Jingyun Liu1Kaijia Chen2Nannan Zhong3Chengpeng He4Xinming Luan5Xiaobei Zang6Jianbo Sun7Ning Cao8Wenbo Wang9Qiang Ren10Department of Bone Joint, Binzhou Medical University HospitalDepartment of Orthopedics, Liaocheng People’s HospitalDepartment of Bone Joint, Binzhou Medical University HospitalSchool of Materials and Engineering, China University of Petroleum (East China)School of Materials and Engineering, China University of Petroleum (East China)School of Materials and Engineering, China University of Petroleum (East China)School of Materials and Engineering, China University of Petroleum (East China)School of Materials and Engineering, China University of Petroleum (East China)School of Materials and Engineering, China University of Petroleum (East China)Department of Orthopedics, The Second Affiliated Hospital of Shandong, University of Traditional Chinese MedicineDepartment of Bone Joint, Binzhou Medical University HospitalAbstract This study examines the biocompatibility, osteogenic potential, and effectiveness of polyether ether ketone (PEEK) composites for treating osteonecrosis, seeking to establish a theoretical basis for clinical application. A range of PEEK composite materials, including sulfonated polyether ether ketone (SPEEK), polydopamine-sulfonated polyether ether ketone (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-BFP), and vascular endothelial growth factor-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-VEGF), were constructed by concentrated sulfuric acid sulfonation, polydopamine modification and grafting of bioactive factors. The experiments involved adult male New Zealand rabbits aged 24–28 weeks and weighing 2.6–4 kg. The SPEEK-PDA-BFP possesses the smallest water contact angle, indicating the highest hydrophilicity, with its surface characterized by a rich density of clustered BFP particles. The SPEEK-PDA-BFP exhibits superior adhesion, proliferation, and differentiation capabilities, along with pronounced bacteriostatic effects, which are attributed to its dense particle clusters. The SPEEK-PDA-BFP facilitates the formation of regular and dense bone trabeculae. Comparative study on treating osteonecrosis with SPEEK-PDA-VEGF and SPEEK-PDA-BFP highlighted the superior formation of mature bone trabeculae and angiogenic protein CD31 around SPEEK-PDA-VEGF. The PEEK composite materials have good biocompatibility, osteogenic activity and bone repair activity. In particular, SPEEK-PDA-VEGF composite materials have the best effect on bone repair.https://doi.org/10.1038/s41598-025-86965-1Polyether ether ketone (PEEK)Surface modificationBone forming peptide (BFP)Vascular endothelial growth factor (VEGF)Osteonecrosis |
| spellingShingle | Yi Sun Jingyun Liu Kaijia Chen Nannan Zhong Chengpeng He Xinming Luan Xiaobei Zang Jianbo Sun Ning Cao Wenbo Wang Qiang Ren Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair Scientific Reports Polyether ether ketone (PEEK) Surface modification Bone forming peptide (BFP) Vascular endothelial growth factor (VEGF) Osteonecrosis |
| title | Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair |
| title_full | Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair |
| title_fullStr | Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair |
| title_full_unstemmed | Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair |
| title_short | Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair |
| title_sort | polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair |
| topic | Polyether ether ketone (PEEK) Surface modification Bone forming peptide (BFP) Vascular endothelial growth factor (VEGF) Osteonecrosis |
| url | https://doi.org/10.1038/s41598-025-86965-1 |
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