A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser
Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external light irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by the photothermal conversion efficiency of the material. In this study, we developed...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000468 |
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| author | Shengsheng Cui Xinni Pan Shanshan Fan Cheng Cao Yingao Jiao Yanfei Fu Jiaqi Niu Shujin Lin Jingmao Lao Yanlei Liu |
| author_facet | Shengsheng Cui Xinni Pan Shanshan Fan Cheng Cao Yingao Jiao Yanfei Fu Jiaqi Niu Shujin Lin Jingmao Lao Yanlei Liu |
| author_sort | Shengsheng Cui |
| collection | DOAJ |
| description | Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external light irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by the photothermal conversion efficiency of the material. In this study, we developed a novel ladder-type conjugated polymer, PPAPA, via a phenazine ring fusion reaction. PPAPA exhibits a high photothermal conversion efficiency of 75.2 % under 1064 nm laser irradiation, comparable to the benchmark organic photothermal agent SWCNT. Notably, the synthesis of PPAPA avoids the use of noble metal catalysts, eliminating potential biotoxicity caused by residual catalysts and ensuring optimal photothermal stability and efficiency. Furthermore, PPAPA demonstrates efficient photothermal conversion under near-infrared II (NIR-II) 1064 nm laser irradiation, enabling deeper tissue penetration and reduced tissue absorption. This work comprehensively investigates the photothermal properties of PPAPA and evaluates its efficacy in tumor PTT, demonstrating its potential as a novel and effective therapeutic strategy for cancer treatment, offering new hope for patients. |
| format | Article |
| id | doaj-art-b5981d4a3f1142e680425cc8d7dd80a9 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-b5981d4a3f1142e680425cc8d7dd80a92025-01-23T05:27:38ZengElsevierMaterials Today Bio2590-00642025-04-0131101488A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laserShengsheng Cui0Xinni Pan1Shanshan Fan2Cheng Cao3Yingao Jiao4Yanfei Fu5Jiaqi Niu6Shujin Lin7Jingmao Lao8Yanlei Liu9Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China; National Engineering Center for Nanotechnology, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaInstitute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR ChinaGastrointestinal Surgery, The First People's Hospital of Qinzhou, Qinzhou, 535000, PR China; Corresponding author.Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China; National Engineering Center for Nanotechnology, Shanghai, 200240, PR China; Corresponding author. Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China.Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external light irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by the photothermal conversion efficiency of the material. In this study, we developed a novel ladder-type conjugated polymer, PPAPA, via a phenazine ring fusion reaction. PPAPA exhibits a high photothermal conversion efficiency of 75.2 % under 1064 nm laser irradiation, comparable to the benchmark organic photothermal agent SWCNT. Notably, the synthesis of PPAPA avoids the use of noble metal catalysts, eliminating potential biotoxicity caused by residual catalysts and ensuring optimal photothermal stability and efficiency. Furthermore, PPAPA demonstrates efficient photothermal conversion under near-infrared II (NIR-II) 1064 nm laser irradiation, enabling deeper tissue penetration and reduced tissue absorption. This work comprehensively investigates the photothermal properties of PPAPA and evaluates its efficacy in tumor PTT, demonstrating its potential as a novel and effective therapeutic strategy for cancer treatment, offering new hope for patients.http://www.sciencedirect.com/science/article/pii/S2590006425000468Conjugated polymerPhenazine ring fusion reactionPhotothermal therapy |
| spellingShingle | Shengsheng Cui Xinni Pan Shanshan Fan Cheng Cao Yingao Jiao Yanfei Fu Jiaqi Niu Shujin Lin Jingmao Lao Yanlei Liu A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser Materials Today Bio Conjugated polymer Phenazine ring fusion reaction Photothermal therapy |
| title | A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser |
| title_full | A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser |
| title_fullStr | A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser |
| title_full_unstemmed | A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser |
| title_short | A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser |
| title_sort | novel conjugated polymer synthesized via a noble metal free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near infrared nir ii laser |
| topic | Conjugated polymer Phenazine ring fusion reaction Photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000468 |
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