ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation

ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation

Abstract Acute rejection (AR) is a significant complication in liver transplantation, impacting graft function and patient survival. Kupffer cells (KCs), liver-specific macrophages, can polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes, both of which critically influence AR outcom...

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Bibliographic Details
Main Authors: Weifeng Huang, Liqing Jiang, Yingsong Jiang, Shanshan Li, Wanqi Liu, Kezhen Zong, Dadi Peng, Zhongjun Wu, Zuotian Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Liver transplantation
Acute rejection
ANGPTL4
NF-κB
Inflammation
Online Access:https://doi.org/10.1038/s41598-024-81832-x
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https://doi.org/10.1038/s41598-024-81832-x

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