Macrophages and macrophage extracellular vesicles confer cancer ferroptosis resistance via PRDX6-mediated mitophagy inhibition

Ferroptosis has emerged as a promising therapeutic target in cancer therapy, with the tumor microenvironment (TME) playing a pivotal role in regulating ferroptosis. Although macrophages contribute to ferroptosis regulation within TME, the underlying mechanisms remain unclear. In this study, we demon...

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Bibliographic Details
Main Authors: Naisheng Zheng, Fuli Li, Qing Huang, Xian Huang, Tomasz Maj
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725003398
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