Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy
Abstract Background Bisphosphonate (BP) can treat osteoporosis and prevent osteoporotic fractures in clinical. However, the effect of BP on microstructure and mechanical properties of cortical and trabecular bone has been taken little attention, separately. Methods In this study, BP was used to inte...
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BMC
2024-09-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-024-07846-8 |
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| author | Yuzhu Wang Zhanglin Wu Chun Li Chenhao Ma Jingyang Chen Mincong Wang Dawei Gao Yufeng Wu Haibin Wang |
| author_facet | Yuzhu Wang Zhanglin Wu Chun Li Chenhao Ma Jingyang Chen Mincong Wang Dawei Gao Yufeng Wu Haibin Wang |
| author_sort | Yuzhu Wang |
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| description | Abstract Background Bisphosphonate (BP) can treat osteoporosis and prevent osteoporotic fractures in clinical. However, the effect of BP on microstructure and mechanical properties of cortical and trabecular bone has been taken little attention, separately. Methods In this study, BP was used to intervene in ovariectomized female SD rats. The femoral micro-CT images were used to measure the structural parameters and reconstruct the 3D models in volume of interest. The structural parameters of cortical and trabecular bone were measured, and the mechanical properties were predicted using micro-finite element analysis. Results There was almost no significant difference in the morphological structure parameters and mechanical properties of cortical bone between normal, ovariectomized (sham-OVX) and BP intervention groups. However, BP could significantly improve bone volume fraction (BV/TV) and trabecular separation (Tb.SP) in inter-femoral condyles (IT) (sham-OVX vs. BP, p < 0.001), and had no significant effect on BV/TV in medial and lateral femoral condyles (MT, LT). Similarly, BPs could significantly affect the effective modulus in IT (sham-OVX vs. BP, p < 0.001), and had no significant difference in MT and LT. In addition, the structural parameters and effective modulus showed a good linear correlation. Conclusion In a short time, the effects of BP intervention and osteoporosis on cortical bone were not obvious. The effects of BP on trabecular bone in non-main weight-bearing area (IT) were valuable, while for osteoporosis, the main weight-bearing area (MT, LT) may improve the structural quality and mechanical strength of trabecular bone through exercise compensation. |
| format | Article |
| id | doaj-art-b56e52a9bfc042e38f378d5f03e62149 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-b56e52a9bfc042e38f378d5f03e621492025-01-26T12:09:59ZengBMCBMC Musculoskeletal Disorders1471-24742024-09-0125111210.1186/s12891-024-07846-8Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomyYuzhu Wang0Zhanglin Wu1Chun Li2Chenhao Ma3Jingyang Chen4Mincong Wang5Dawei Gao6Yufeng Wu7Haibin Wang8Department of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic Surgery, The Fifth Affiliated Hospital of Southern Medical UniversityDepartment of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic Surgery, The Fifth Affiliated Hospital of Southern Medical UniversityDepartment of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic Surgery, First Affiliated Hospital, Guangzhou University of Chinese MedicineAbstract Background Bisphosphonate (BP) can treat osteoporosis and prevent osteoporotic fractures in clinical. However, the effect of BP on microstructure and mechanical properties of cortical and trabecular bone has been taken little attention, separately. Methods In this study, BP was used to intervene in ovariectomized female SD rats. The femoral micro-CT images were used to measure the structural parameters and reconstruct the 3D models in volume of interest. The structural parameters of cortical and trabecular bone were measured, and the mechanical properties were predicted using micro-finite element analysis. Results There was almost no significant difference in the morphological structure parameters and mechanical properties of cortical bone between normal, ovariectomized (sham-OVX) and BP intervention groups. However, BP could significantly improve bone volume fraction (BV/TV) and trabecular separation (Tb.SP) in inter-femoral condyles (IT) (sham-OVX vs. BP, p < 0.001), and had no significant effect on BV/TV in medial and lateral femoral condyles (MT, LT). Similarly, BPs could significantly affect the effective modulus in IT (sham-OVX vs. BP, p < 0.001), and had no significant difference in MT and LT. In addition, the structural parameters and effective modulus showed a good linear correlation. Conclusion In a short time, the effects of BP intervention and osteoporosis on cortical bone were not obvious. The effects of BP on trabecular bone in non-main weight-bearing area (IT) were valuable, while for osteoporosis, the main weight-bearing area (MT, LT) may improve the structural quality and mechanical strength of trabecular bone through exercise compensation.https://doi.org/10.1186/s12891-024-07846-8BisphosphonateBone microstructureMechanical strengthOsteoporosis |
| spellingShingle | Yuzhu Wang Zhanglin Wu Chun Li Chenhao Ma Jingyang Chen Mincong Wang Dawei Gao Yufeng Wu Haibin Wang Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy BMC Musculoskeletal Disorders Bisphosphonate Bone microstructure Mechanical strength Osteoporosis |
| title | Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy |
| title_full | Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy |
| title_fullStr | Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy |
| title_full_unstemmed | Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy |
| title_short | Effect of bisphosphonate on bone microstructure, mechanical strength in osteoporotic rats by ovariectomy |
| title_sort | effect of bisphosphonate on bone microstructure mechanical strength in osteoporotic rats by ovariectomy |
| topic | Bisphosphonate Bone microstructure Mechanical strength Osteoporosis |
| url | https://doi.org/10.1186/s12891-024-07846-8 |
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