Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7346030 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564847775055872 |
|---|---|
| author | Ying Wang Lili Wang Haoyu Yang Weichang Yuan Jingyi Ren Yanping Bai |
| author_facet | Ying Wang Lili Wang Haoyu Yang Weichang Yuan Jingyi Ren Yanping Bai |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions. In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted. Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment. |
| format | Article |
| id | doaj-art-b55e2cc430b54f13b1f72023ae0a09d3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b55e2cc430b54f13b1f72023ae0a09d32025-02-03T01:10:08ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/73460307346030Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with PsoriasisYing Wang0Lili Wang1Haoyu Yang2Weichang Yuan3Jingyi Ren4Yanping Bai5Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, ChinaClinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, ChinaBeijing University of Chinese Medicine, No. 11, Bei San Huan East Road, Chaoyang District, Beijing 100029, ChinaBeijing University of Chinese Medicine, No. 11, Bei San Huan East Road, Chaoyang District, Beijing 100029, ChinaDepartment of Orthopedics, Taian Chinese Medicine Hospital, No. 58, Dongyue Street, Taishan District, Taian 271000, ChinaClinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, ChinaCirculating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions. In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted. Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment.http://dx.doi.org/10.1155/2016/7346030 |
| spellingShingle | Ying Wang Lili Wang Haoyu Yang Weichang Yuan Jingyi Ren Yanping Bai Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis Journal of Immunology Research |
| title | Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis |
| title_full | Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis |
| title_fullStr | Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis |
| title_full_unstemmed | Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis |
| title_short | Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis |
| title_sort | activated circulating t follicular helper cells are associated with disease severity in patients with psoriasis |
| url | http://dx.doi.org/10.1155/2016/7346030 |
| work_keys_str_mv | AT yingwang activatedcirculatingtfollicularhelpercellsareassociatedwithdiseaseseverityinpatientswithpsoriasis AT liliwang activatedcirculatingtfollicularhelpercellsareassociatedwithdiseaseseverityinpatientswithpsoriasis AT haoyuyang activatedcirculatingtfollicularhelpercellsareassociatedwithdiseaseseverityinpatientswithpsoriasis AT weichangyuan activatedcirculatingtfollicularhelpercellsareassociatedwithdiseaseseverityinpatientswithpsoriasis AT jingyiren activatedcirculatingtfollicularhelpercellsareassociatedwithdiseaseseverityinpatientswithpsoriasis AT yanpingbai activatedcirculatingtfollicularhelpercellsareassociatedwithdiseaseseverityinpatientswithpsoriasis |