ATF1 and miR-27b-3p drive intervertebral disc degeneration through the PPARG/NF-κB signaling axis

Abstract Intervertebral disc degeneration (IDD) is a primary cause of degenerative disc disease; however, the mechanisms underlying it remain unknown. Although great efforts have been made to develop new regenerative therapies, their clinical success is limited. Recent research has indicated that mi...

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Bibliographic Details
Main Authors: Wei Guo, Kun Mu, Jing-Chao Geng, Hai-Yang Xing, Yu Dong, Wen-Dong Liu, Shuan-Chi Wang, Jia-Xiao Shi, Bao-Rui Xing, Jian-Yong Zhao, Xiao-Ming Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08186-6
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