Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms

Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms

Abstract Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) present unique challenges due to their heterogeneity and limited treatment options. Oncolytic virotherapy has emerged as a promising therapeutic for other NETs and thus, we sought to investigate the potential of an engineered oncolytic...

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Main Authors: Colin H. Quinn, Janet R. Julson, Michael H. Erwin, Hooper R. Markert, Larua V. Bownes, Jerry E. Stewart, Sorina Shirley, Karina J. Yoon, Jamie M. Aye, James M. Markert, Elizabeth A. Beierle
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Neuroendocrine tumors
Oncolytic virus
Patient derived xenografts
Translational research
Online Access:https://doi.org/10.1038/s41598-025-98588-7
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https://doi.org/10.1038/s41598-025-98588-7

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