The molecular mechanism of gemcitabine in inhibiting the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway for ovarian cancer treatment

The molecular mechanism of gemcitabine in inhibiting the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway for ovarian cancer treatment

Abstract Ovarian cancer is a common malignant tumor in women, exhibiting a certain sensitivity to chemotherapy drugs like gemcitabine (GEM). This study, through the analysis of ovarian cancer single-cell RNA sequencing (scRNA-seq) data and transcriptome data post-GEM treatment, identifies the pivota...

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Bibliographic Details
Main Authors: Liangliang Wang, Shanshan Ma, Huiwen Su, Dandan Nie, Lihua Wang
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Ovarian cancer
Gemcitabine
Hypoxia-inducible factor 1 alpha
Vascular endothelial growth factor B
Fibroblast growth factor 2
Fibroblast growth factor receptor 1
Online Access:https://doi.org/10.1007/s12672-024-01723-5
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https://doi.org/10.1007/s12672-024-01723-5

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