Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer

Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer

Abstract The incidence of prostate cancer (PCa) is high among elderly men. Cepharanthine hydrochloride (CH) is recognized for its important role in the prevention and treatment of various diseases. However, its effects and mechanisms of action in the context of PCa remain unclear. Our study aims to...

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Bibliographic Details
Main Authors: Zongming Dong, Xiaosa Chang, Xing Luo, Hui Li, Ming Deng, Zeyu Huang, Tingting Chen, Yu Chen, Bishao Sun, Yingbing Wu, Ronghua Wu, Qingjian Wu, Jingzhen Zhu, Ji Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Cepharanthine hydrochloride
Prostate cancer
Mechanism investigations
Network pharmacology
Transcriptomics
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-03004-9
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https://doi.org/10.1038/s41598-025-03004-9

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