Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin
In vertebrates, numerous processes occur in a rhythmic manner. The hormonal signal reliably reflecting the environmental light conditions is melatonin. Nocturnal melatonin secretion patterns could be disturbed in pathophysiological states, including inflammation, Alzheimer’s disease, and depression....
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/2589483 |
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| author | A. P. Herman J. Bochenek K. Król A. Krawczyńska H. Antushevich B. Pawlina A. Herman K. Romanowicz D. Tomaszewska-Zaremba |
| author_facet | A. P. Herman J. Bochenek K. Król A. Krawczyńska H. Antushevich B. Pawlina A. Herman K. Romanowicz D. Tomaszewska-Zaremba |
| author_sort | A. P. Herman |
| collection | DOAJ |
| description | In vertebrates, numerous processes occur in a rhythmic manner. The hormonal signal reliably reflecting the environmental light conditions is melatonin. Nocturnal melatonin secretion patterns could be disturbed in pathophysiological states, including inflammation, Alzheimer’s disease, and depression. All of these states share common elements in their aetiology, including the overexpression of interleukin- (IL-) 1β in the central nervous system. Therefore, the present study was designed to determine the effect of the central injection of exogenous IL-1β on melatonin release and on the expression of the enzymes of the melatonin biosynthetic pathway in the pineal gland of ewe. It was found that intracerebroventricular injections of IL-1β (50 µg/animal) suppressed (P<0.05) nocturnal melatonin secretion in sheep regardless of the photoperiod. This may have resulted from decreased (P<0.05) synthesis of the melatonin intermediate serotonin, which may have resulted, at least partially, from a reduced expression of tryptophan hydroxylase. IL-1β also inhibited (P<0.05) the expression of the melatonin rhythm enzyme arylalkylamine-N-acetyltransferase and hydroxyindole-O-methyltransferase. However, the ability of IL-1β to affect the expression of these enzymes was dependent upon the photoperiod. Our study may shed new light on the role of central IL-1β in the aetiology of disruptions in melatonin secretion. |
| format | Article |
| id | doaj-art-b509cf3e249345c9a61e0946ebbcc42a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b509cf3e249345c9a61e0946ebbcc42a2025-02-03T01:00:36ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/25894832589483Central Interleukin-1β Suppresses the Nocturnal Secretion of MelatoninA. P. Herman0J. Bochenek1K. Król2A. Krawczyńska3H. Antushevich4B. Pawlina5A. Herman6K. Romanowicz7D. Tomaszewska-Zaremba8The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Academy of Cosmetics and Health Care, 13 Podwale Street, 00-252 Warsaw, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, PolandIn vertebrates, numerous processes occur in a rhythmic manner. The hormonal signal reliably reflecting the environmental light conditions is melatonin. Nocturnal melatonin secretion patterns could be disturbed in pathophysiological states, including inflammation, Alzheimer’s disease, and depression. All of these states share common elements in their aetiology, including the overexpression of interleukin- (IL-) 1β in the central nervous system. Therefore, the present study was designed to determine the effect of the central injection of exogenous IL-1β on melatonin release and on the expression of the enzymes of the melatonin biosynthetic pathway in the pineal gland of ewe. It was found that intracerebroventricular injections of IL-1β (50 µg/animal) suppressed (P<0.05) nocturnal melatonin secretion in sheep regardless of the photoperiod. This may have resulted from decreased (P<0.05) synthesis of the melatonin intermediate serotonin, which may have resulted, at least partially, from a reduced expression of tryptophan hydroxylase. IL-1β also inhibited (P<0.05) the expression of the melatonin rhythm enzyme arylalkylamine-N-acetyltransferase and hydroxyindole-O-methyltransferase. However, the ability of IL-1β to affect the expression of these enzymes was dependent upon the photoperiod. Our study may shed new light on the role of central IL-1β in the aetiology of disruptions in melatonin secretion.http://dx.doi.org/10.1155/2016/2589483 |
| spellingShingle | A. P. Herman J. Bochenek K. Król A. Krawczyńska H. Antushevich B. Pawlina A. Herman K. Romanowicz D. Tomaszewska-Zaremba Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin Mediators of Inflammation |
| title | Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin |
| title_full | Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin |
| title_fullStr | Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin |
| title_full_unstemmed | Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin |
| title_short | Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin |
| title_sort | central interleukin 1β suppresses the nocturnal secretion of melatonin |
| url | http://dx.doi.org/10.1155/2016/2589483 |
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