Making the Most of Major Histocompatibility Complex Molecule Multimers: Applications in Type 1 Diabetes

Making the Most of Major Histocompatibility Complex Molecule Multimers: Applications in Type 1 Diabetes

Classical major histocompatibility complex (MHC) class I and II molecules present peptides to cognate T-cell receptors on the surface of T lymphocytes. The specificity with which T cells recognize peptide-MHC (pMHC) complexes has allowed for the utilization of recombinant, multimeric pMHC ligands fo...

Full description

Saved in:

Bibliographic Details
Main Authors:	Greg S. Gojanovich, Paul R. Hess
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Series:	Clinical and Developmental Immunology
Online Access:	http://dx.doi.org/10.1155/2012/380289
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Mass Spectrometric Characterization of Peptides Associated with Molecules of the Major Histocompatibility Complex
by: Michael R. Pisano, et al.
Published: (2017-08-01)

The Major Histocompatibility Complex in Transplantation
by: Marco Antonio Ayala García, et al.
Published: (2012-01-01)

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.
by: Daniel C Chapman, et al.
Published: (2015-01-01)

Concurrent detection of circulating minor histocompatibility antigen-specific CD8+ T cells in SCT recipients by combinatorial encoding MHC multimers.
by: Kelly Broen, et al.
Published: (2011-01-01)

DNA barcoded peptide-MHC multimers to measure and monitor minor histocompatibility antigen-specific T cells after allogeneic stem cell transplantation
by: Sine R Hadrup, et al.
Published: (2024-12-01)

Major Histocompatibility Complex Class II Deficiency Beyond Infancy
by: Aziza Bachir Kattra, et al.
Published: (2025-01-01)

A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth.
by: Lorraine R Washburn, et al.
Published: (2011-03-01)

Association of Major Histocompatibility Complex Polymorphism With Acute Phase Response in Broiler Chicken
by: Afra Vatankhah, et al.
Published: (2024-11-01)

Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.
by: Naoya Yuhki, et al.
Published: (2008-07-01)

Interferon-gamma-activated macrophages infected with Burkholderia cenocepacia process and present bacterial antigens to T-cells by class I and II major histocompatibility complex molecules
by: Roberto Rosales-Reyes, et al.
Published: (2020-01-01)

SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA
by: A. V. Karaulov, et al.
Published: (2010-03-01)

Characterization and transcription of non-classical class I major histocompatibility complex (MHC) genes in buffaloes
by: L. S. S. Ribeiro, et al.
Published: (2025-03-01)

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.
by: Nikolaos A Patsopoulos, et al.
Published: (2013-11-01)

Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells
by: F. A. Omarova, et al.
Published: (2023-06-01)

Major histocompatibility complex I upregulation in clear cell renal cell carcinoma is associated with increased survival
by: Rishi R. Sekar, et al.
Published: (2016-04-01)

Two polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteins.
by: Alistair Bailey, et al.
Published: (2014-01-01)

Using major histocompatibility complex (MHC) II expression to predict antitumor response to CD4 + lymphocyte depletion
by: Yanping Wang, et al.
Published: (2025-02-01)

Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population.
by: Ashley H Beecham, et al.
Published: (2022-01-01)

The chicken major histocompatibility complex (MHC-B) and alloantigen systems A, D, E, and I impact resistance to coccidiosis
by: Abhisek Niraula, et al.
Published: (2025-07-01)

Distribution of Major Histocompatibility Complex Alleles in Cohorts of Patients with Different Levels of Post-Vaccination Antibodies against Hepatitis B
by: N. V. Vlasenko, et al.
Published: (2024-07-01)

Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition
by: Anna Rapacz-Leonard, et al.
Published: (2014-01-01)

Allelic variants of genes of the main histocompatibility complex in children with type 1 diabetes mellitus who became ill at preschool age
by: D. N. Laptev, et al.
Published: (2024-09-01)

Erratum to “Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition”
by: Anna Rapacz-Leonard, et al.
Published: (2014-01-01)

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
by: Lisa F Barcellos, et al.
Published: (2009-10-01)

Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies.
by: Demin Li, et al.
Published: (2017-01-01)

Matings Between Individuals with Similar Major Histocompatibility Complex (MHC) Improve Offspring Survival in the Rainbow Trout (<i>Oncorhynchus mykiss</i>)
by: Cinzia Bergamino, et al.
Published: (2024-10-01)

β-hairpin-mediated formation of structurally distinct multimers of neurotoxic prion peptides.
by: Andrew C Gill
Published: (2014-01-01)

Graduate Student Literature Review: The DRB3 gene of the bovine major histocompatibility complex—Discovery, diversity, and distribution of alleles in commercial breeds of cattle and applications for development of vaccines*
by: Thales Eduardo Galdino Andrade, et al.
Published: (2024-12-01)

Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis
by: Rubén Queiro, et al.
Published: (2013-01-01)

The Transcription of Transposable Elements Differentially Regulated by SVAs in the Major Histocompatibility Complex Class I Region of a Parkinson’s Progression Markers Initiative Cohort
by: Jerzy K. Kulski, et al.
Published: (2025-01-01)

Deep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS
by: Myriam Rahmouni, et al.
Published: (2025-01-01)

The same human complement factor B allele of major histocompatibility complex (MHC) class III allele is conserved in chimpanzee and gorilla, stressing its immune importance
by: Antonio Arnaiz-Villena, et al.
Published: (2025-02-01)

Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles
by: Milita Darguzyte, et al.
Published: (2024-10-01)

HLA-E: A Novel Player for Histocompatibility
by: Thomas Kraemer, et al.
Published: (2014-01-01)

Restoration and functional analysis of the SGI1 resolution system – SGI1 multimers are eliminated by the reactivated resolution
by: Alexandra Veress, et al.
Published: (2025-07-01)

Suppressing Colloidal Quantum Dot Multimer Fusion Leads to High‐Performance InSb Infrared Photodetectors
by: Lucheng Peng, et al.
Published: (2025-07-01)

In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma
by: Xin Wang, et al.
Published: (2024-12-01)

Exploring the interplay of T cell receptor-V gene copy numbers and major histocompatibility complex selection pressure in avian species: Insights into immune system evolution and reproductive investment
by: Lin Sun, et al.
Published: (2024-01-01)

Cryo-Electron Microscopy of BfpB Reveals a Type IVb Secretin Multimer Adapted to Accommodate the Exceptionally Wide Bundle-Forming Pilus
by: Janay I. Little, et al.
Published: (2025-05-01)

Making the most of grasslands and heathlands
by: Doyle McKey
Published: (2021-12-01)