Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals

Choice of activation protocol impacts the yield and quality of CAR T cell product, particularly with older individuals

Abstract Objectives In clinical chimeric antigen receptor (CAR) T cell therapy, one of the strongest correlates of favorable patient responses is lower levels of differentiation in T cells from the peripheral blood mononuclear cell (PBMC) starting material or the CAR T cell product. T cells from old...

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Bibliographic Details
Main Authors: Palak H Mehta, Gemma S Trollope, Patrick Leung, Shivali Savita Chinni, Anna Iasinskaia, Aaron J Harrison, Hannah Hughes‐Parry, Misty R Jenkins, Michael H Kershaw, Anthony Jaworowski, Clare Y Slaney, Rachel M Koldej, David S Ritchie, Kylie M Quinn
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Clinical & Translational Immunology
Subjects:
ageing
CAR T cell
CD28
T cell activation
Online Access:https://doi.org/10.1002/cti2.70016
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https://doi.org/10.1002/cti2.70016

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