Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/201514 |
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| _version_ | 1832554380505645056 |
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| author | Naguib Salleh Nelli Giribabu |
| author_facet | Naguib Salleh Nelli Giribabu |
| author_sort | Naguib Salleh |
| collection | DOAJ |
| description | Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception. |
| format | Article |
| id | doaj-art-b4db93fac6bf46b0881a9f6860716ae4 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b4db93fac6bf46b0881a9f6860716ae42025-02-03T05:51:37ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/201514201514Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal ContraceptionNaguib Salleh0Nelli Giribabu1Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaLeukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.http://dx.doi.org/10.1155/2014/201514 |
| spellingShingle | Naguib Salleh Nelli Giribabu Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception The Scientific World Journal |
| title | Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception |
| title_full | Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception |
| title_fullStr | Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception |
| title_full_unstemmed | Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception |
| title_short | Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception |
| title_sort | leukemia inhibitory factor roles in embryo implantation and in nonhormonal contraception |
| url | http://dx.doi.org/10.1155/2014/201514 |
| work_keys_str_mv | AT naguibsalleh leukemiainhibitoryfactorrolesinembryoimplantationandinnonhormonalcontraception AT nelligiribabu leukemiainhibitoryfactorrolesinembryoimplantationandinnonhormonalcontraception |