Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma

Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma

Abstract Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) are effective for EGFR-mutant lung adenocarcinoma (LUAD), resistance inevitably develops through diverse mechanisms, including secondary genetic mutations, amplifications and as-yet undefined processes. To comprehensively unravel the mech...

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Main Authors: Taro Shinozaki, Kazuhiro Togasaki, Junko Hamamoto, Akifumi Mitsuishi, Takahiro Fukushima, Kai Sugihara, Toshiki Ebisudani, Masahiko Okada, Ayaka Saito, Lisa Shigematsu, Hatsuyo Takaoka, Fumimaro Ito, Keiko Ohgino, Kota Ishioka, Kageaki Watanabe, Tsunekazu Hishima, Yutaka Kurebayashi, Katsura Emoto, Hideki Terai, Shinnosuke Ikemura, Ichiro Kawada, Keisuke Asakura, Tomoyuki Hishida, Hisao Asamura, Yuki Ohta, Sirirat Takahashi, Mayumi Oda, Megumu Saito, Mami Matano, Kenzo Soejima, Masayuki Fujii, Koichi Fukunaga, Hiroyuki Yasuda, Toshiro Sato
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59623-3
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https://doi.org/10.1038/s41467-025-59623-3

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