Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome
In this study, we found that the CD8+CD45RA+CCR7− T cell subpopulation was increased in the peripheral blood of patients with primary Sjögren's syndrome (pSS) compared with healthy donors. Moreover, both CD8+TIM-3+ T cells and CD8+CD45RA+CCR7− T cells were positively correlated with serum anti-...
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| Language: | English |
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Elsevier
2025-05-01
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| Series: | Immunobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171298525000488 |
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| author | Jie Pan Rongqiang Wu Liuyang He Yu Bai Jun Ding Yan Wang Shu Fan Zhengyu Zhang Ping Zhang Chunjian Qi |
| author_facet | Jie Pan Rongqiang Wu Liuyang He Yu Bai Jun Ding Yan Wang Shu Fan Zhengyu Zhang Ping Zhang Chunjian Qi |
| author_sort | Jie Pan |
| collection | DOAJ |
| description | In this study, we found that the CD8+CD45RA+CCR7− T cell subpopulation was increased in the peripheral blood of patients with primary Sjögren's syndrome (pSS) compared with healthy donors. Moreover, both CD8+TIM-3+ T cells and CD8+CD45RA+CCR7− T cells were positively correlated with serum anti-SSA antibody concentrations in patients. In animal experiments, prolonged administration of β-glucan (whole glucan particle [WGP]) effectively reduced the onset and progression of pSS. Compared with the control group, the WGP-treated group showed a significant reduction in the proportions of CD4+PD-1+ T cells, CD4+TIM-3+ T cells, CD8+PD-1+ T cells, CD8+TIM-3+ T cells, and CD8+CD45RA+CCR7− T cells in the spleens and peripheral blood of non-obese diabetic mice. Notably, β-glucan exhibited therapeutic efficacy comparable to that of hydroxychloroquine sulfate, a conventional treatment for pSS. These findings suggest that the CD8+CD45RA+CCR7− T cell subpopulation may represent a promising new therapeutic target for the disease. |
| format | Article |
| id | doaj-art-b4a342c6d79f4473a7e5f5ec24f889d2 |
| institution | Kabale University |
| issn | 0171-2985 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Immunobiology |
| spelling | doaj-art-b4a342c6d79f4473a7e5f5ec24f889d22025-08-20T03:26:09ZengElsevierImmunobiology0171-29852025-05-01230315291410.1016/j.imbio.2025.152914Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndromeJie Pan0Rongqiang Wu1Liuyang He2Yu Bai3Jun Ding4Yan Wang5Shu Fan6Zhengyu Zhang7Ping Zhang8Chunjian Qi9Basic Research Center, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaDepartment of Clinical Laboratory, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaBasic Research Center, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaBasic Research Center, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaBasic Research Center, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaDepartment of Clinical Laboratory, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaDepartment of Clinical Laboratory, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaDepartment of Rheumatology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaDepartment of Clinical Laboratory, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, ChinaBasic Research Center, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, China; Corresponding author at: Basic Research Center, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, China.In this study, we found that the CD8+CD45RA+CCR7− T cell subpopulation was increased in the peripheral blood of patients with primary Sjögren's syndrome (pSS) compared with healthy donors. Moreover, both CD8+TIM-3+ T cells and CD8+CD45RA+CCR7− T cells were positively correlated with serum anti-SSA antibody concentrations in patients. In animal experiments, prolonged administration of β-glucan (whole glucan particle [WGP]) effectively reduced the onset and progression of pSS. Compared with the control group, the WGP-treated group showed a significant reduction in the proportions of CD4+PD-1+ T cells, CD4+TIM-3+ T cells, CD8+PD-1+ T cells, CD8+TIM-3+ T cells, and CD8+CD45RA+CCR7− T cells in the spleens and peripheral blood of non-obese diabetic mice. Notably, β-glucan exhibited therapeutic efficacy comparable to that of hydroxychloroquine sulfate, a conventional treatment for pSS. These findings suggest that the CD8+CD45RA+CCR7− T cell subpopulation may represent a promising new therapeutic target for the disease.http://www.sciencedirect.com/science/article/pii/S0171298525000488Sjögren's syndromeT Cell SubsetΒ-GlucanHydroxychloroquine sulfate |
| spellingShingle | Jie Pan Rongqiang Wu Liuyang He Yu Bai Jun Ding Yan Wang Shu Fan Zhengyu Zhang Ping Zhang Chunjian Qi Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome Immunobiology Sjögren's syndrome T Cell Subset Β-Glucan Hydroxychloroquine sulfate |
| title | Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome |
| title_full | Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome |
| title_fullStr | Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome |
| title_full_unstemmed | Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome |
| title_short | Alterations in CD8+CD45RA+CCR7− T cells as a potential biomarker for primary Sjögren's syndrome |
| title_sort | alterations in cd8 cd45ra ccr7 t cells as a potential biomarker for primary sjogren s syndrome |
| topic | Sjögren's syndrome T Cell Subset Β-Glucan Hydroxychloroquine sulfate |
| url | http://www.sciencedirect.com/science/article/pii/S0171298525000488 |
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