Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction

The TFAMoplex is a nanoparticulate gene delivery system based on the mitochondrial transcription factor A (TFAM) protein, which can be engineered with various functional domains to enhance plasmid DNA transfection. In this study, we aimed at improving the TFAMoplex system by incorporating basic leuc...

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Bibliographic Details
Main Authors: Steffen Honrath, Miguel Heussi, Lukas Beckert, David Scherer, Roderick Y.H. Lim, Michael Burger, Jean-Christophe Leroux
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
gene therapy
nonviral gene delivery
protein-based transfection TFAMoplex
protein engineering
adeno-associated virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125000800
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