G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis

Summary: Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled w...

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Main Authors: Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724015298
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