The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice
The major pathologic hallmark of the alcoholic liver disease (ALD) is the representation of chronic alcohol-induced hepatocyte lipid accumulation. This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia (ACT) in chronic alcohol-ind...
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Tsinghua University Press
2021-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000598 |
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| author | Yange Liu Ronglong Chen Lanzhou Li Ruitao Dong Hui Yin Yawen Wang Anhui Yang Jianbin Wang Changtian Li Di Wang |
| author_facet | Yange Liu Ronglong Chen Lanzhou Li Ruitao Dong Hui Yin Yawen Wang Anhui Yang Jianbin Wang Changtian Li Di Wang |
| author_sort | Yange Liu |
| collection | DOAJ |
| description | The major pathologic hallmark of the alcoholic liver disease (ALD) is the representation of chronic alcohol-induced hepatocyte lipid accumulation. This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia (ACT) in chronic alcohol-induced liver injury mice, establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks. In long-term alcohol consumption mice, the significantly lost body weight, increased organ indexes, hepatic alanine aminotransferase and aspartate aminotransferase levels were all remissed after 6-week ACT orally administration, showing its hepatoprotective property. ACT suppressed the triglyceride, total cholesterol and low-density lipoprotein levels, and enhanced high-density lipoprotein levels in serum or/and liver of chronic alcohol damaged mice. Combining with the pathological observations, ACT displayed an anti-steatosis effects to restrain the progress of ALD. Based on proteomic analysis and enzyme-linked immunosorbent assay, ACT had been confirmed to regulate the levels of lipid biogeneration-related factors and depressed the over-accumulation of hepatic reactive oxygen species. According to further data, ACT prevented alcoholic liver injury may be associated with mediating lipid metabolism-related to PGC-1α and NF-κB signaling. In summary, ACT protected the body against chronic alcohol ingest induced liver injury through its regulation lipid on metabolism. |
| format | Article |
| id | doaj-art-b444d1a9551c4021bd6f4615e56d9aae |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b444d1a9551c4021bd6f4615e56d9aae2025-02-03T06:49:36ZengTsinghua University PressFood Science and Human Wellness2213-45302021-07-01104497507The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 miceYange Liu0Ronglong Chen1Lanzhou Li2Ruitao Dong3Hui Yin4Yawen Wang5Anhui Yang6Jianbin Wang7Changtian Li8Di Wang9School of Basic Medical Sciences, Nanchang University, Nanchang 330038, China; School of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Basic Medical Sciences, Nanchang University, Nanchang 330038, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaSchool of Basic Medical Sciences, Nanchang University, Nanchang 330038, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Basic Medical Sciences, Nanchang University, Nanchang 330038, ChinaEngineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China; Corresponding author.School of Life Sciences, Jilin University, Changchun 130012, China; Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China; Corresponding author.The major pathologic hallmark of the alcoholic liver disease (ALD) is the representation of chronic alcohol-induced hepatocyte lipid accumulation. This study aims to investigate the hepatoprotective role of triterpenoids-enriched extracts from Antrodia cinnamomea mycelia (ACT) in chronic alcohol-induced liver injury mice, establishing in C57BL/6 mice through gradient alcohol feeding for 24 weeks. In long-term alcohol consumption mice, the significantly lost body weight, increased organ indexes, hepatic alanine aminotransferase and aspartate aminotransferase levels were all remissed after 6-week ACT orally administration, showing its hepatoprotective property. ACT suppressed the triglyceride, total cholesterol and low-density lipoprotein levels, and enhanced high-density lipoprotein levels in serum or/and liver of chronic alcohol damaged mice. Combining with the pathological observations, ACT displayed an anti-steatosis effects to restrain the progress of ALD. Based on proteomic analysis and enzyme-linked immunosorbent assay, ACT had been confirmed to regulate the levels of lipid biogeneration-related factors and depressed the over-accumulation of hepatic reactive oxygen species. According to further data, ACT prevented alcoholic liver injury may be associated with mediating lipid metabolism-related to PGC-1α and NF-κB signaling. In summary, ACT protected the body against chronic alcohol ingest induced liver injury through its regulation lipid on metabolism.http://www.sciencedirect.com/science/article/pii/S2213453021000598Antrodia cinnamomea myceliaTriterpenoidsChronic alcohol-induced liver injuryLipid accumulation |
| spellingShingle | Yange Liu Ronglong Chen Lanzhou Li Ruitao Dong Hui Yin Yawen Wang Anhui Yang Jianbin Wang Changtian Li Di Wang The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice Food Science and Human Wellness Antrodia cinnamomea mycelia Triterpenoids Chronic alcohol-induced liver injury Lipid accumulation |
| title | The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice |
| title_full | The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice |
| title_fullStr | The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice |
| title_full_unstemmed | The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice |
| title_short | The triterpenoids-enriched extracts from Antrodia cinnamomea mycelia attenuate alcohol-induced chronic liver injury via suppression lipid accumulation in C57BL/6 mice |
| title_sort | triterpenoids enriched extracts from antrodia cinnamomea mycelia attenuate alcohol induced chronic liver injury via suppression lipid accumulation in c57bl 6 mice |
| topic | Antrodia cinnamomea mycelia Triterpenoids Chronic alcohol-induced liver injury Lipid accumulation |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000598 |
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