Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

Abstract The von Hippel-Lindau (VHL) tumor suppressor is a substrate-defining component of E3 ubiquitin ligase complexes that target cellular substrates for proteasome-mediated degradation. VHL inactivation by mutation or transcriptional silencing is observed in most sporadic cases of clear cell ren...

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Main Authors: Mercy Akuma, Minjun Kim, Chenxuan Zhu, Ellis Wiljer, Antoine Gaudreau-Lapierre, Leshan D. Patterson, Lars Egevad, Simon Tanguay, Laura Trinkle-Mulcahy, William L. Stanford, Yasser Riazalhosseini, Ryan C. Russell
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07623-y
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https://doi.org/10.1038/s41419-025-07623-y

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