Relationship between programmed cell death ligand 1 expression and the number of biopsy specimens in advanced gastric cancer

Relationship between programmed cell death ligand 1 expression and the number of biopsy specimens in advanced gastric cancer

Abstract Purpose Programmed cell death ligand 1 (PD-L1) expression in advanced gastric cancer (AGC) exhibits spatial heterogeneity, which may lead to sampling bias during biopsies. Although multiple biopsies are believed to improve the accuracy of PD-L1 assessment, the optimal number of specimens re...

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Main Authors: Taro Mizuno, Yukiya Narita, Yasunobu Ishizuka, Tomoki Sakakida, Kazunori Honda, Toshiki Masuishi, Hiroya Taniguchi, Shigenori Kadowaki, Masashi Ando, Masahiro Tajika, Kei Muro
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Journal of Cancer Research and Clinical Oncology
Subjects:
Advanced gastric cancer
PD-L1 CPS
Biopsy specimen count
Online Access:https://doi.org/10.1007/s00432-025-06255-1
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https://doi.org/10.1007/s00432-025-06255-1

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