Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation
The increased level of plasma total homocysteine (tHcy) in chronic kidney disease patients has been reported as a new and independent risk factor for cardiovascular disease. However, after the description of reverse epidemiology in the renal population, the association of tHcy and nutrition became l...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2010/957645 |
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| author | Ana de Lurdes Agostinho Cabrita Vieira Alexandre Baptista Anabela Malho Ana Pinho Ana Paula Silva Idalécio Bernardo Pedro Leão Neves |
| author_facet | Ana de Lurdes Agostinho Cabrita Vieira Alexandre Baptista Anabela Malho Ana Pinho Ana Paula Silva Idalécio Bernardo Pedro Leão Neves |
| author_sort | Ana de Lurdes Agostinho Cabrita Vieira |
| collection | DOAJ |
| description | The increased level of plasma total homocysteine (tHcy) in chronic kidney disease patients has been reported as a new and independent risk factor for cardiovascular disease. However, after the description of reverse epidemiology in the renal population, the association of tHcy and nutrition became less clear. We evaluated the association between homocysteine, nutritional status, and inflammation, and their impact on mortality in 95 predialysis patients. High sensitivity C-Reactive Protein (hs-CRP), interleukin 6 (IL-6), Tumor Necrosis Factor 𝛼 (TNF-𝛼)], and tHcy were evaluated, as was the nutritional status by the modified Subjective Global Nutritional Assessment (mSGA). We divided our population in four groups according to their tHcy and mSGA values being above or below the mean level and found the lowest survival in the group with tHcy and mSGA above the mean level, as well as higher levels of IL-6 (𝑃=.03) and TNF-𝛼 (𝑃=.045). Higher levels of homocysteine can be associated with higher mortality in predialysis patients, as long as they are associated with malnutrition and inflammation. |
| format | Article |
| id | doaj-art-b40b65f71ab94d07babb84a13a540ee6 |
| institution | Kabale University |
| issn | 2090-2158 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-b40b65f71ab94d07babb84a13a540ee62025-02-03T05:51:30ZengWileyInternational Journal of Nephrology2090-21582010-01-01201010.4061/2010/957645957645Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and InflammationAna de Lurdes Agostinho Cabrita Vieira0Alexandre Baptista1Anabela Malho2Ana Pinho3Ana Paula Silva4Idalécio Bernardo5Pedro Leão Neves6Serviço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalServiço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalServiço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalServiço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalServiço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalServiço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalServiço de Nefrologia, Hospital de Faro, Algarve, Rua Leão Penedo, 8000-342 Faro, PortugalThe increased level of plasma total homocysteine (tHcy) in chronic kidney disease patients has been reported as a new and independent risk factor for cardiovascular disease. However, after the description of reverse epidemiology in the renal population, the association of tHcy and nutrition became less clear. We evaluated the association between homocysteine, nutritional status, and inflammation, and their impact on mortality in 95 predialysis patients. High sensitivity C-Reactive Protein (hs-CRP), interleukin 6 (IL-6), Tumor Necrosis Factor 𝛼 (TNF-𝛼)], and tHcy were evaluated, as was the nutritional status by the modified Subjective Global Nutritional Assessment (mSGA). We divided our population in four groups according to their tHcy and mSGA values being above or below the mean level and found the lowest survival in the group with tHcy and mSGA above the mean level, as well as higher levels of IL-6 (𝑃=.03) and TNF-𝛼 (𝑃=.045). Higher levels of homocysteine can be associated with higher mortality in predialysis patients, as long as they are associated with malnutrition and inflammation.http://dx.doi.org/10.4061/2010/957645 |
| spellingShingle | Ana de Lurdes Agostinho Cabrita Vieira Alexandre Baptista Anabela Malho Ana Pinho Ana Paula Silva Idalécio Bernardo Pedro Leão Neves Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation International Journal of Nephrology |
| title | Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation |
| title_full | Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation |
| title_fullStr | Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation |
| title_full_unstemmed | Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation |
| title_short | Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation |
| title_sort | homocysteine is a risk factor in predialysis patients when associated with malnutrition and inflammation |
| url | http://dx.doi.org/10.4061/2010/957645 |
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