IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells

Abstract IRX3 is linked to predisposition to obesity through the FTO locus and is upregulated during early adipogenesis in risk-allele carriers, shifting adipocyte fate toward fat storage. However, how this elevated IRX3 expression influences later developmental stages remains unclear. Here we show...

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Main Authors: Jan-Inge Bjune, Samantha Laber, Laurence Lawrence-Archer, Patrizia M. C. Nothnagel, Shuntaro Yamada, Xu Zhao, Pouda Panahandeh Strømland, Niyaz Al-Sharabi, Kamal Mustafa, Pål R. Njølstad, Melina Claussnitzer, Roger D. Cox, Pierre Chymkowitch, Gunnar Mellgren, Simon N. Dankel
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62361-1
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https://doi.org/10.1038/s41467-025-62361-1

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