A computational assessment of alkaloids targeting the plant homeodomain in pygopus2: inhibitory potential and drug-like properties

A computational assessment of alkaloids targeting the plant homeodomain in pygopus2: inhibitory potential and drug-like properties

<p>Pygopus2 (Pygo2) is a component of the Wnt signaling pathway, crucial for β-catenin-mediated transcription during normal development. Overexpression of Pygo2 has been linked to various human cancers, including lung, colon, and brain cancers. The plant homeodomain (PHD) finger in Pygo2 inter...

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Bibliographic Details
Main Authors: Zechariah Oresanya, Olaide Odesanya, Ibrahim Olaniyi, Christian Agbojo, God's Will Eleanya, Rahmon Kanmodi
Format: Article
Language:English
Published: Academy Publishing Center 2024-09-01
Series:Advances in Medical, Pharmaceutical and Dental Research
Subjects:
discorhabdin w
binding affinities
molecular dynamics
lipinski
hinge regions
Online Access:http://apc.aast.edu/ojs/index.php/AMPDR/article/view/923
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http://apc.aast.edu/ojs/index.php/AMPDR/article/view/923

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