Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance
Alterations of B cell subpopulations have been described up to date as characterizing advanced stage of HIV-1 infection. However, whether such defects are relevant in subjects with a preserved number of CD4+ T cells (>350 cells/μL) is unclear. In a cross-sectional study, we investigated if signs...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/829584 |
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| author | Manuela Fogli Carlo Torti Fabio Malacarne Simona Fiorentini Melania Albani Ilaria Izzo Cinzia Giagulli Fabrizio Maggi Giampiero Carosi Arnaldo Caruso |
| author_facet | Manuela Fogli Carlo Torti Fabio Malacarne Simona Fiorentini Melania Albani Ilaria Izzo Cinzia Giagulli Fabrizio Maggi Giampiero Carosi Arnaldo Caruso |
| author_sort | Manuela Fogli |
| collection | DOAJ |
| description | Alterations of B cell subpopulations have been described up to date as characterizing advanced stage of HIV-1 infection. However, whether such defects are relevant in subjects with a preserved number of CD4+ T cells (>350 cells/μL) is unclear. In a cross-sectional study, we investigated if signs of B cells exhaustion and impaired viral immune surveillance are present in a cohort of 43 asymptomatic HIV-1-infected patients with preserved CD4+ T cell counts (>350 cells/μL) and highly active antiretroviral therapy (HAART) untreated. A dramatic expansion of exhausted tissue-like memory B cells (CD10-CD21lowCD27-) was observed. B cells alteration was related to an increase in Torque teno virus (TTV) load, used as surrogate marker of immune function. Successfully HAART-treated patients showed normalization of B cell subpopulations frequency and TTV load. These results provide new insights on B cell in HIV-1 infection and show that development of B cell abnormalities precedes CD4+ T cell decline. |
| format | Article |
| id | doaj-art-b3ddca1dee934105bde0c721434baeae |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Clinical and Developmental Immunology |
| spelling | doaj-art-b3ddca1dee934105bde0c721434baeae2025-02-03T01:24:01ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/829584829584Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune SurveillanceManuela Fogli0Carlo Torti1Fabio Malacarne2Simona Fiorentini3Melania Albani4Ilaria Izzo5Cinzia Giagulli6Fabrizio Maggi7Giampiero Carosi8Arnaldo Caruso9Section of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalyInstitute of Infectious Tropical Diseases, School of Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalySection of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalySection of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalyVirology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, 35-37 San Zeno Road, 56127 Pisa, ItalyInstitute of Infectious Tropical Diseases, School of Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalySection of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalyVirology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, 35-37 San Zeno Road, 56127 Pisa, ItalyInstitute of Infectious Tropical Diseases, School of Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalySection of Microbiology, Department of Experimental and Applied Medicine, University of Brescia, Spedali Civili Square, 25123 Brescia, ItalyAlterations of B cell subpopulations have been described up to date as characterizing advanced stage of HIV-1 infection. However, whether such defects are relevant in subjects with a preserved number of CD4+ T cells (>350 cells/μL) is unclear. In a cross-sectional study, we investigated if signs of B cells exhaustion and impaired viral immune surveillance are present in a cohort of 43 asymptomatic HIV-1-infected patients with preserved CD4+ T cell counts (>350 cells/μL) and highly active antiretroviral therapy (HAART) untreated. A dramatic expansion of exhausted tissue-like memory B cells (CD10-CD21lowCD27-) was observed. B cells alteration was related to an increase in Torque teno virus (TTV) load, used as surrogate marker of immune function. Successfully HAART-treated patients showed normalization of B cell subpopulations frequency and TTV load. These results provide new insights on B cell in HIV-1 infection and show that development of B cell abnormalities precedes CD4+ T cell decline.http://dx.doi.org/10.1155/2012/829584 |
| spellingShingle | Manuela Fogli Carlo Torti Fabio Malacarne Simona Fiorentini Melania Albani Ilaria Izzo Cinzia Giagulli Fabrizio Maggi Giampiero Carosi Arnaldo Caruso Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance Clinical and Developmental Immunology |
| title | Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance |
| title_full | Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance |
| title_fullStr | Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance |
| title_full_unstemmed | Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance |
| title_short | Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance |
| title_sort | emergence of exhausted b cells in asymptomatic hiv 1 infected patients naive for haart is related to reduced immune surveillance |
| url | http://dx.doi.org/10.1155/2012/829584 |
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