A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations
Background: Increasing evidence points to a negative correlation between K-ras mutations and patient’s response to, or survival benefit after, treatment with EGFR-inhibitors. Therefore, rapid and reliable assays for mutational analysis of the K-ras gene are strongly needed.
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0466 |
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| _version_ | 1832556212883816448 |
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| author | D. Kramer F. B. Thunnissen M. I. Gallegos-Ruiz E. F. Smit P. E. Postmus C. J. L. M. Meijer P.J.F. Snijders D. A. M. Heideman |
| author_facet | D. Kramer F. B. Thunnissen M. I. Gallegos-Ruiz E. F. Smit P. E. Postmus C. J. L. M. Meijer P.J.F. Snijders D. A. M. Heideman |
| author_sort | D. Kramer |
| collection | DOAJ |
| description | Background: Increasing evidence points to a negative correlation between K-ras mutations and patient’s response to, or survival benefit after, treatment with EGFR-inhibitors. Therefore, rapid and reliable assays for mutational analysis of the K-ras gene are strongly needed. |
| format | Article |
| id | doaj-art-b3dca800acbe4d7e9877d48b2e718323 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-b3dca800acbe4d7e9877d48b2e7183232025-02-03T05:45:58ZengWileyCellular Oncology1570-58701875-86062009-01-0131316116710.3233/CLO-2009-0466A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras MutationsD. Kramer0F. B. Thunnissen1M. I. Gallegos-Ruiz2E. F. Smit3P. E. Postmus4C. J. L. M. Meijer5P.J.F. Snijders6D. A. M. Heideman7Department of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Medical Oncology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pulmonary Diseases, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pulmonary Diseases, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsBackground: Increasing evidence points to a negative correlation between K-ras mutations and patient’s response to, or survival benefit after, treatment with EGFR-inhibitors. Therefore, rapid and reliable assays for mutational analysis of the K-ras gene are strongly needed.http://dx.doi.org/10.3233/CLO-2009-0466 |
| spellingShingle | D. Kramer F. B. Thunnissen M. I. Gallegos-Ruiz E. F. Smit P. E. Postmus C. J. L. M. Meijer P.J.F. Snijders D. A. M. Heideman A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations Cellular Oncology |
| title | A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations |
| title_full | A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations |
| title_fullStr | A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations |
| title_full_unstemmed | A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations |
| title_short | A Fast, Sensitive and Accurate High Resolution Melting (HRM) Technology-Based Assay to Screen for Common K-ras Mutations |
| title_sort | fast sensitive and accurate high resolution melting hrm technology based assay to screen for common k ras mutations |
| url | http://dx.doi.org/10.3233/CLO-2009-0466 |
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