Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights int...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/169506 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565123816882176 |
|---|---|
| author | Anne Bugge Susanne Mandrup |
| author_facet | Anne Bugge Susanne Mandrup |
| author_sort | Anne Bugge |
| collection | DOAJ |
| description | The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1. |
| format | Article |
| id | doaj-art-b3d07965a5294564b29c259cea52a939 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-b3d07965a5294564b29c259cea52a9392025-02-03T01:09:12ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/169506169506Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific TransactivationAnne Bugge0Susanne Mandrup1Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, DenmarkDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, DenmarkThe peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.http://dx.doi.org/10.1155/2010/169506 |
| spellingShingle | Anne Bugge Susanne Mandrup Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation PPAR Research |
| title | Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation |
| title_full | Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation |
| title_fullStr | Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation |
| title_full_unstemmed | Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation |
| title_short | Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation |
| title_sort | molecular mechanisms and genome wide aspects of ppar subtype specific transactivation |
| url | http://dx.doi.org/10.1155/2010/169506 |
| work_keys_str_mv | AT annebugge molecularmechanismsandgenomewideaspectsofpparsubtypespecifictransactivation AT susannemandrup molecularmechanismsandgenomewideaspectsofpparsubtypespecifictransactivation |