Deciphering the dark cancer phosphoproteome using machine-learned co-regulation of phosphosites

Abstract Mass spectrometry-based phosphoproteomics offers a comprehensive view of protein phosphorylation, yet our limited knowledge about the regulation and function of most phosphosites hampers the extraction of meaningful biological insights. To address this challenge, we integrate machine learni...

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Bibliographic Details
Main Authors: Wen Jiang, Eric J. Jaehnig, Yuxing Liao, Zhiao Shi, Tomer M. Yaron-Barir, Jared L. Johnson, Lewis C. Cantley, Bing Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57993-2
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