Cytokine changes in patients with heatstroke during pilgrimage to Makkah
Circulating levels and role of IL-6, IL-1ra, TNFsr-II and CRP in patients with heatstroke is not fully known. This study correlated levels of these mediators with outcome in 26 patients. In survivors (n=20), IL-6 concentration declined on cooling, whereas in non-survivors levels continued to increas...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791839 |
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| author | I. A. Hashim A. Al-Zeer S. Al-Shohaib M. Al-Ahwal A. Shenkin |
| author_facet | I. A. Hashim A. Al-Zeer S. Al-Shohaib M. Al-Ahwal A. Shenkin |
| author_sort | I. A. Hashim |
| collection | DOAJ |
| description | Circulating levels and role of IL-6, IL-1ra, TNFsr-II and CRP in patients with heatstroke is not fully known. This study correlated levels of these mediators with outcome in 26 patients. In survivors (n=20), IL-6 concentration declined on cooling, whereas in non-survivors levels continued to increase at 6 h following admission before declining. Admission TNFsr-II concentrations in survivors were significantly lower than non-survivors and levels continued to rise in both groups. IL-1ra levels were markedly elevated in both groups. Changes in cytokine levels were not influenced by renal function. Elevated C-reactive protein levels were observed for both groups and remained so despite cooling, furthermore, there was no correlation with alanine aminotransferase levels. The study demonstrated the elevation of the above mediators and suggested a role in the pathogenesis of heatstroke. Markedly elevated levels or those that remained elevated despite cooling were associated with mortality. |
| format | Article |
| id | doaj-art-b3b77488215d42dd9e4d2cf04a5d03dc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b3b77488215d42dd9e4d2cf04a5d03dc2025-02-03T01:07:45ZengWileyMediators of Inflammation0962-93511466-18611997-01-016213513910.1080/09629359791839Cytokine changes in patients with heatstroke during pilgrimage to MakkahI. A. Hashim0A. Al-Zeer1S. Al-Shohaib2M. Al-Ahwal3A. Shenkin4Department of Pathology, King Khalid National Guard Hospital, P.O. Box 9515, Jeddah 21423, Saudi ArabiaIntensive Care Unit, King Khalid University Hospital, Riyadh, Saudi ArabiaDepartment of Medicine, King Khalid National Guard Hospital, P.O. Box 9515, Jeddah 21423, Saudi ArabiaDepartment of Medicine, King Abdelaziz University Hospital, Jeddah, Saudi ArabiaDepartment of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, UKCirculating levels and role of IL-6, IL-1ra, TNFsr-II and CRP in patients with heatstroke is not fully known. This study correlated levels of these mediators with outcome in 26 patients. In survivors (n=20), IL-6 concentration declined on cooling, whereas in non-survivors levels continued to increase at 6 h following admission before declining. Admission TNFsr-II concentrations in survivors were significantly lower than non-survivors and levels continued to rise in both groups. IL-1ra levels were markedly elevated in both groups. Changes in cytokine levels were not influenced by renal function. Elevated C-reactive protein levels were observed for both groups and remained so despite cooling, furthermore, there was no correlation with alanine aminotransferase levels. The study demonstrated the elevation of the above mediators and suggested a role in the pathogenesis of heatstroke. Markedly elevated levels or those that remained elevated despite cooling were associated with mortality.http://dx.doi.org/10.1080/09629359791839 |
| spellingShingle | I. A. Hashim A. Al-Zeer S. Al-Shohaib M. Al-Ahwal A. Shenkin Cytokine changes in patients with heatstroke during pilgrimage to Makkah Mediators of Inflammation |
| title | Cytokine changes in patients with heatstroke during pilgrimage to Makkah |
| title_full | Cytokine changes in patients with heatstroke during pilgrimage to Makkah |
| title_fullStr | Cytokine changes in patients with heatstroke during pilgrimage to Makkah |
| title_full_unstemmed | Cytokine changes in patients with heatstroke during pilgrimage to Makkah |
| title_short | Cytokine changes in patients with heatstroke during pilgrimage to Makkah |
| title_sort | cytokine changes in patients with heatstroke during pilgrimage to makkah |
| url | http://dx.doi.org/10.1080/09629359791839 |
| work_keys_str_mv | AT iahashim cytokinechangesinpatientswithheatstrokeduringpilgrimagetomakkah AT aalzeer cytokinechangesinpatientswithheatstrokeduringpilgrimagetomakkah AT salshohaib cytokinechangesinpatientswithheatstrokeduringpilgrimagetomakkah AT malahwal cytokinechangesinpatientswithheatstrokeduringpilgrimagetomakkah AT ashenkin cytokinechangesinpatientswithheatstrokeduringpilgrimagetomakkah |