Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis
Background/Objectives: Autoimmune inflammation enhances the electrical instability of the atrial myocardium in patients with systemic sclerosis (SSc); thus, atrial arrhythmia risk is increased, which might be predicted by evaluating the P wave interval and dispersion of a 12-lead surface electrocard...
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MDPI AG
2025-01-01
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| author | Veronika Sebestyén Dóra Ujvárosy Balázs Ratku Hajnalka Lőrincz Sára Csiha Dóra Tari Gyöngyike Majai Sándor Somodi Gabriella Szűcs Mariann Harangi Zoltán Szabó |
| author_facet | Veronika Sebestyén Dóra Ujvárosy Balázs Ratku Hajnalka Lőrincz Sára Csiha Dóra Tari Gyöngyike Majai Sándor Somodi Gabriella Szűcs Mariann Harangi Zoltán Szabó |
| author_sort | Veronika Sebestyén |
| collection | DOAJ |
| description | Background/Objectives: Autoimmune inflammation enhances the electrical instability of the atrial myocardium in patients with systemic sclerosis (SSc); thus, atrial arrhythmia risk is increased, which might be predicted by evaluating the P wave interval and dispersion of a 12-lead surface electrocardiogram (ECG). Methods: We examined 26 SSc patients and 36 healthy controls and measured the P wave interval and P wave dispersion of the 12-lead surface ECG in each patient. Furthermore, echocardiography and 24-h Holter ECG were performed and levels of inflammatory laboratory parameters, including serum progranulin (PGRN), sVCAM-1, sICAM-1, leptin and C-reactive protein (CRP), were determined. Lipid parameters, such as Apo A-I, LDL-cholesterol (LDL-C), oxidized LDL (oxLDL) and the LDL and HDL subfractions were also evaluated. Results: The P wave interval showed a significant positive correlation with the levels of Apo A-I, LDL-C, CRP, sVCAM-1, sICAM-1 and leptin. The oxLDL level correlated positively with P wave dispersion. Of note, significant positive correlation was also found between the large HDL percentage and the P wave interval. Conclusions: Our results suggest that PGRN, sVCAM-1, sICAM-1, leptin, CRP, LDL-C and oxLDL, along with LDL and HDL subfractions, might have a role in atrial arrhythmogenesis in patients with SSc. |
| format | Article |
| id | doaj-art-b397c64219014e76bd3811c92c1e2e64 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-b397c64219014e76bd3811c92c1e2e642025-01-24T13:24:27ZengMDPI AGBiomedicines2227-90592025-01-0113122010.3390/biomedicines13010220Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic SclerosisVeronika Sebestyén0Dóra Ujvárosy1Balázs Ratku2Hajnalka Lőrincz3Sára Csiha4Dóra Tari5Gyöngyike Majai6Sándor Somodi7Gabriella Szűcs8Mariann Harangi9Zoltán Szabó10Department of Emergency Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Emergency Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Emergency Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDivision of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDivision of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Rheumatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDivision of Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Emergency Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryDepartment of Rheumatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryFaculty of Health Sciences, Institute of Health Studies, University of Debrecen, 4032 Debrecen, HungaryDepartment of Emergency Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, HungaryBackground/Objectives: Autoimmune inflammation enhances the electrical instability of the atrial myocardium in patients with systemic sclerosis (SSc); thus, atrial arrhythmia risk is increased, which might be predicted by evaluating the P wave interval and dispersion of a 12-lead surface electrocardiogram (ECG). Methods: We examined 26 SSc patients and 36 healthy controls and measured the P wave interval and P wave dispersion of the 12-lead surface ECG in each patient. Furthermore, echocardiography and 24-h Holter ECG were performed and levels of inflammatory laboratory parameters, including serum progranulin (PGRN), sVCAM-1, sICAM-1, leptin and C-reactive protein (CRP), were determined. Lipid parameters, such as Apo A-I, LDL-cholesterol (LDL-C), oxidized LDL (oxLDL) and the LDL and HDL subfractions were also evaluated. Results: The P wave interval showed a significant positive correlation with the levels of Apo A-I, LDL-C, CRP, sVCAM-1, sICAM-1 and leptin. The oxLDL level correlated positively with P wave dispersion. Of note, significant positive correlation was also found between the large HDL percentage and the P wave interval. Conclusions: Our results suggest that PGRN, sVCAM-1, sICAM-1, leptin, CRP, LDL-C and oxLDL, along with LDL and HDL subfractions, might have a role in atrial arrhythmogenesis in patients with SSc.https://www.mdpi.com/2227-9059/13/1/220systemic sclerosisatrial arrhythmiasinflammationleptinoxLDLLDL and HDL subfractions |
| spellingShingle | Veronika Sebestyén Dóra Ujvárosy Balázs Ratku Hajnalka Lőrincz Sára Csiha Dóra Tari Gyöngyike Majai Sándor Somodi Gabriella Szűcs Mariann Harangi Zoltán Szabó Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis Biomedicines systemic sclerosis atrial arrhythmias inflammation leptin oxLDL LDL and HDL subfractions |
| title | Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis |
| title_full | Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis |
| title_fullStr | Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis |
| title_full_unstemmed | Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis |
| title_short | Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis |
| title_sort | inflammatory biomarkers and lipid parameters may predict an increased risk for atrial arrhythmias in patients with systemic sclerosis |
| topic | systemic sclerosis atrial arrhythmias inflammation leptin oxLDL LDL and HDL subfractions |
| url | https://www.mdpi.com/2227-9059/13/1/220 |
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