Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

ObjectivesHepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its clinical use and contributing to its related morbidity and mortality. This study investigated the hepatoprotective effects of nitazoxanide (NTZ), an antiprotozoal drug, against MTX-induced hepatotoxicity and whe...

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Main Authors: Nevertyty Mohamed Mahmoud, Shimaa M. Elshazly, Fatma El-shaarawy, Sawsan A. Zaitone, Afaf A. Aldahish, Gehan A. Ahmed, Manal S. Fawzy, Sheka Yagub Aloyouni, Sally Y. Abed, Tahani Saeedi, Shaimaa S. El-Sayed
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
nitazoxanide
methotrexate
hepatotoxicity
endoplasmic reticulum stress
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1491249/full
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