Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice
Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, hav...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2021/6666018 |
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| author | Domenico Rizzo Enrico Ravera Marco Fragai Giacomo Parigi Claudio Luchinat |
| author_facet | Domenico Rizzo Enrico Ravera Marco Fragai Giacomo Parigi Claudio Luchinat |
| author_sort | Domenico Rizzo |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents. We have characterized the relaxometry profiles of pineapple juice in order to understand the origin of the increase in relaxation rates (and thus of the MRI contrast) in reference to its content of manganese ions. Furthermore, we have characterized the relaxometry profiles of pineapple juice in the presence of alginate in different amounts; the interaction of the manganese ions with alginate slows down their reorientation time to some extent, with a subsequent increase in the relaxation rates. The relaxometry profiles were also compared with those of manganese(II) solutions in 50 mmol/dm3 sodium acetate solution (same pH of pineapple juice), which revealed sizable differences, mostly in the number of water molecules coordinated to the metal ion, their lifetimes, and in the constant of the Fermi-contact interaction. Finally, the fit of the transverse relaxivity shows that the increased viscosity in the hydrogel formulations can improve significantly the negative contrast of pineapple juice at the magnetic fields relevant for clinical MRI. |
| format | Article |
| id | doaj-art-b36e23e7c0eb4a0d9663e4e0d64df689 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-b36e23e7c0eb4a0d9663e4e0d64df6892025-02-03T05:49:17ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2021-01-01202110.1155/2021/66660186666018Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple JuiceDomenico Rizzo0Enrico Ravera1Marco Fragai2Giacomo Parigi3Claudio Luchinat4Magnetic Resonance Center (CERM), Department of Chemistry, University of Florence, Via Sacconi 6, Sesto Fiorentino, Florence, ItalyMagnetic Resonance Center (CERM), Department of Chemistry, University of Florence, Via Sacconi 6, Sesto Fiorentino, Florence, ItalyMagnetic Resonance Center (CERM), Department of Chemistry, University of Florence, Via Sacconi 6, Sesto Fiorentino, Florence, ItalyMagnetic Resonance Center (CERM), Department of Chemistry, University of Florence, Via Sacconi 6, Sesto Fiorentino, Florence, ItalyMagnetic Resonance Center (CERM), Department of Chemistry, University of Florence, Via Sacconi 6, Sesto Fiorentino, Florence, ItalyMagnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents. We have characterized the relaxometry profiles of pineapple juice in order to understand the origin of the increase in relaxation rates (and thus of the MRI contrast) in reference to its content of manganese ions. Furthermore, we have characterized the relaxometry profiles of pineapple juice in the presence of alginate in different amounts; the interaction of the manganese ions with alginate slows down their reorientation time to some extent, with a subsequent increase in the relaxation rates. The relaxometry profiles were also compared with those of manganese(II) solutions in 50 mmol/dm3 sodium acetate solution (same pH of pineapple juice), which revealed sizable differences, mostly in the number of water molecules coordinated to the metal ion, their lifetimes, and in the constant of the Fermi-contact interaction. Finally, the fit of the transverse relaxivity shows that the increased viscosity in the hydrogel formulations can improve significantly the negative contrast of pineapple juice at the magnetic fields relevant for clinical MRI.http://dx.doi.org/10.1155/2021/6666018 |
| spellingShingle | Domenico Rizzo Enrico Ravera Marco Fragai Giacomo Parigi Claudio Luchinat Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice Bioinorganic Chemistry and Applications |
| title | Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice |
| title_full | Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice |
| title_fullStr | Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice |
| title_full_unstemmed | Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice |
| title_short | Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice |
| title_sort | origin of the mri contrast in natural and hydrogel formulation of pineapple juice |
| url | http://dx.doi.org/10.1155/2021/6666018 |
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