Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients
Background and purpose: This study aimed to compare the post-irradiation secondary cancer rates of boron neutron capture therapy (BNCT), proton beam therapy (PBT), and X-ray therapy (XT) in pediatric and Adolescent and Young Adult (AYA) patients with intracranial lesions. Materials and methods: BNCT...
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| Format: | Article |
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Elsevier
2025-03-01
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| Series: | Clinical and Translational Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630825000114 |
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| author | Shunsuke Suzuki Shintaro Shiba Hiroki Tanaka Masashi Yamanaka Kazuki Matsumoto Koichi Tokuuye Motoko Omura |
| author_facet | Shunsuke Suzuki Shintaro Shiba Hiroki Tanaka Masashi Yamanaka Kazuki Matsumoto Koichi Tokuuye Motoko Omura |
| author_sort | Shunsuke Suzuki |
| collection | DOAJ |
| description | Background and purpose: This study aimed to compare the post-irradiation secondary cancer rates of boron neutron capture therapy (BNCT), proton beam therapy (PBT), and X-ray therapy (XT) in pediatric and Adolescent and Young Adult (AYA) patients with intracranial lesions. Materials and methods: BNCT, PBT, and XT plans were optimized for nine pediatric and AYA patients with intracranial lesions. The BNCT dose calculation results were biologically effective dose converted. Lifetime attributable risk (LAR) was calculated using a calculation model proposed by Schneider et al. Statistical analysis was performed using log-linear model with mixed effects. Organs included in the radiation field were the brain, bones, and soft tissue. The difference in LAR between the three treatments for each organ and the number needed to treat (NNT), as an indicator of the number of cases required to achieve the effect of suppressing the occurrence of secondary cancers, was calculated and evaluated. Results: Statistically significant differences between BNCT vs PBT and XT were confirmed for the brain, bone, soft tissue, and cumulative (P < 0.0001). Significant differences were also observed in PBT and XT, with P < 0.0001 for brain and cumulative, P = 0.0002 for bone, and P = 0.0281 for soft tissue. The cumulative NNT for BNCT vs. PBT, BNCT vs. XT, and PBT vs. XT were 162, 78.6, and 153, respectively. Conclusion: BNCT had a significantly lower LAR compared to PBT and XT. These findings suggest the usefulness of BNCT in pediatric and AYA patients with brain tumors from the perspective of post-irradiation secondary cancer. |
| format | Article |
| id | doaj-art-b361e8be5dd14ee2a3fbc22cdeb9749f |
| institution | Kabale University |
| issn | 2405-6308 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj-art-b361e8be5dd14ee2a3fbc22cdeb9749f2025-01-30T05:14:32ZengElsevierClinical and Translational Radiation Oncology2405-63082025-03-0151100921Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patientsShunsuke Suzuki0Shintaro Shiba1Hiroki Tanaka2Masashi Yamanaka3Kazuki Matsumoto4Koichi Tokuuye5Motoko Omura6Department of Medical Physics, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa 247-8533, Japan; Graduate School of Engineering, Kyoto University, Kyoto daigaku-katsura, Nishikyo-ku, Kyoto 615-8530, Japan; Corresponding author at: Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa 247-8533, Japan.Department of Radiation Oncology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa 247-8533, JapanInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori-cho, Osaka, JapanDepartment of Medical Physics, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa 247-8533, JapanDepartment of Medical Physics, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa 247-8533, JapanDepartment of Radiation Oncology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa 247-8533, JapanDepartment of Radiation Oncology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura City, Kanagawa 247-8533, JapanBackground and purpose: This study aimed to compare the post-irradiation secondary cancer rates of boron neutron capture therapy (BNCT), proton beam therapy (PBT), and X-ray therapy (XT) in pediatric and Adolescent and Young Adult (AYA) patients with intracranial lesions. Materials and methods: BNCT, PBT, and XT plans were optimized for nine pediatric and AYA patients with intracranial lesions. The BNCT dose calculation results were biologically effective dose converted. Lifetime attributable risk (LAR) was calculated using a calculation model proposed by Schneider et al. Statistical analysis was performed using log-linear model with mixed effects. Organs included in the radiation field were the brain, bones, and soft tissue. The difference in LAR between the three treatments for each organ and the number needed to treat (NNT), as an indicator of the number of cases required to achieve the effect of suppressing the occurrence of secondary cancers, was calculated and evaluated. Results: Statistically significant differences between BNCT vs PBT and XT were confirmed for the brain, bone, soft tissue, and cumulative (P < 0.0001). Significant differences were also observed in PBT and XT, with P < 0.0001 for brain and cumulative, P = 0.0002 for bone, and P = 0.0281 for soft tissue. The cumulative NNT for BNCT vs. PBT, BNCT vs. XT, and PBT vs. XT were 162, 78.6, and 153, respectively. Conclusion: BNCT had a significantly lower LAR compared to PBT and XT. These findings suggest the usefulness of BNCT in pediatric and AYA patients with brain tumors from the perspective of post-irradiation secondary cancer.http://www.sciencedirect.com/science/article/pii/S2405630825000114Boron neutron capture therapyProton beam therapyX-ray therapySecondary cancerLifetime attributable risk |
| spellingShingle | Shunsuke Suzuki Shintaro Shiba Hiroki Tanaka Masashi Yamanaka Kazuki Matsumoto Koichi Tokuuye Motoko Omura Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients Clinical and Translational Radiation Oncology Boron neutron capture therapy Proton beam therapy X-ray therapy Secondary cancer Lifetime attributable risk |
| title | Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients |
| title_full | Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients |
| title_fullStr | Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients |
| title_full_unstemmed | Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients |
| title_short | Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients |
| title_sort | comparison of lifetime attributable risk of post irradiation secondary cancer of boron neutron capture therapy proton beam therapy and x ray therapy for pediatric and adolescent and young adult patients |
| topic | Boron neutron capture therapy Proton beam therapy X-ray therapy Secondary cancer Lifetime attributable risk |
| url | http://www.sciencedirect.com/science/article/pii/S2405630825000114 |
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