Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics
Abstract Single-cell three-dimensional (3D) genome techniques have advanced our understanding of cell-type-specific chromatin structures in complex tissues, yet current methodologies are limited in cell throughput. Here we introduce a high-throughput single-cell Hi-C (dscHi-C) approach and its trans...
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Main Authors: | Honggui Wu, Maoxu Wang, Yinghui Zheng, X. Sunney Xie |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2025-01-01
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Series: | Cell Discovery |
Online Access: | https://doi.org/10.1038/s41421-025-00770-8 |
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