Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics

Abstract Single-cell three-dimensional (3D) genome techniques have advanced our understanding of cell-type-specific chromatin structures in complex tissues, yet current methodologies are limited in cell throughput. Here we introduce a high-throughput single-cell Hi-C (dscHi-C) approach and its trans...

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Bibliographic Details
Main Authors: Honggui Wu, Maoxu Wang, Yinghui Zheng, X. Sunney Xie
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00770-8
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