Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women
Objective: The aim of the study is to compare Glucagon-Like Peptide-1 levels in polycystic ovarian syndrome patients having diabetes mellitus (DM) and healthy women.Polycystic ovarian syndrome (PCOS) is one of the routine endocrinological disorders of reproductive-aged women and it is associated wi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Rawalpindi Medical University
2024-09-01
|
| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2631 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087048267235328 |
|---|---|
| author | Namra Iqtidar Imran Ali Zaidi Sobia Niaz Javaria Latif Amir Naveed Ayesha Yousaf |
| author_facet | Namra Iqtidar Imran Ali Zaidi Sobia Niaz Javaria Latif Amir Naveed Ayesha Yousaf |
| author_sort | Namra Iqtidar |
| collection | DOAJ |
| description |
Objective: The aim of the study is to compare Glucagon-Like Peptide-1 levels in polycystic ovarian syndrome patients having diabetes mellitus (DM) and healthy women.Polycystic ovarian syndrome (PCOS) is one of the routine endocrinological disorders of reproductive-aged women and it is associated with many problems and complications later in life. A relatively novel peptide hormone which is included in incretins (Gut-derived hormones) is Glucagon-like peptide-1(GLP-1). This gut cells-derived peptide hormone originates from L cells which are endocrine cells in the intestine. The receptors of GLP-1 hormones are found in multiple places. Mostly it is found in islet pancreatic beta-cells, in the brain, in the cardiovascular system, and the lungs. The main function of GLP-1 is the reduction of glucose blood levels during hyper-glycemia through the mechanism of increased secretion of hormone insulin and reduced glucagon hormone secretion. GLP-1 promotes satiation and slows up stomach emptying, and hence reduces post-meal glucose blood levels. Moreover, GLP-1 is required to significantly stimulate GnRH (Gonadotropin Hormone releasing hormone) secretion because of the presence of GLP-1 brain receptors located on the GnRH neurons which cause more LH (Luteinizing hormone) secretion.
Methods: A total of 104 subjects participated in the study. Out of them, 52 had PCOS with DM (Group 2), and 52 were age and weight-matched healthy subjects (Group 1) with no signs of hormonal abnormalities.
Results: Mean ± SD of GLP-1 levels in healthy women was 0.41± 0.04 ng/dl as compared to 0.18± 0.03 ng/dl levels in PCOS with DM (p= <0.05). Mean Fasting blood sugar levels in healthy women were 99.92 ± 4.46 mg/dl as compared to 150.19 ± 30.20 mg/dl in PCOS with DM (p= <0.05).
Conclusion: The study shows low GLP-1 levels are seen in PCOS with DM as compared to healthy women.
|
| format | Article |
| id | doaj-art-b347494e6d2c407eade989627c446141 |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-b347494e6d2c407eade989627c4461412025-02-06T08:34:56ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702024-09-0128310.37939/jrmc.v28i3.2631Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy WomenNamra IqtidarImran Ali ZaidiSobia NiazJavaria LatifAmir NaveedAyesha Yousaf Objective: The aim of the study is to compare Glucagon-Like Peptide-1 levels in polycystic ovarian syndrome patients having diabetes mellitus (DM) and healthy women.Polycystic ovarian syndrome (PCOS) is one of the routine endocrinological disorders of reproductive-aged women and it is associated with many problems and complications later in life. A relatively novel peptide hormone which is included in incretins (Gut-derived hormones) is Glucagon-like peptide-1(GLP-1). This gut cells-derived peptide hormone originates from L cells which are endocrine cells in the intestine. The receptors of GLP-1 hormones are found in multiple places. Mostly it is found in islet pancreatic beta-cells, in the brain, in the cardiovascular system, and the lungs. The main function of GLP-1 is the reduction of glucose blood levels during hyper-glycemia through the mechanism of increased secretion of hormone insulin and reduced glucagon hormone secretion. GLP-1 promotes satiation and slows up stomach emptying, and hence reduces post-meal glucose blood levels. Moreover, GLP-1 is required to significantly stimulate GnRH (Gonadotropin Hormone releasing hormone) secretion because of the presence of GLP-1 brain receptors located on the GnRH neurons which cause more LH (Luteinizing hormone) secretion. Methods: A total of 104 subjects participated in the study. Out of them, 52 had PCOS with DM (Group 2), and 52 were age and weight-matched healthy subjects (Group 1) with no signs of hormonal abnormalities. Results: Mean ± SD of GLP-1 levels in healthy women was 0.41± 0.04 ng/dl as compared to 0.18± 0.03 ng/dl levels in PCOS with DM (p= <0.05). Mean Fasting blood sugar levels in healthy women were 99.92 ± 4.46 mg/dl as compared to 150.19 ± 30.20 mg/dl in PCOS with DM (p= <0.05). Conclusion: The study shows low GLP-1 levels are seen in PCOS with DM as compared to healthy women. https://www.journalrmc.com/index.php/JRMC/article/view/2631 |
| spellingShingle | Namra Iqtidar Imran Ali Zaidi Sobia Niaz Javaria Latif Amir Naveed Ayesha Yousaf Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women Journal of Rawalpindi Medical College |
| title | Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women |
| title_full | Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women |
| title_fullStr | Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women |
| title_full_unstemmed | Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women |
| title_short | Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women |
| title_sort | comparison of glucagon like peptide 1 levels in diabetic women with ovarian polycystic syndrome and healthy women |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2631 |
| work_keys_str_mv | AT namraiqtidar comparisonofglucagonlikepeptide1levelsindiabeticwomenwithovarianpolycysticsyndromeandhealthywomen AT imranalizaidi comparisonofglucagonlikepeptide1levelsindiabeticwomenwithovarianpolycysticsyndromeandhealthywomen AT sobianiaz comparisonofglucagonlikepeptide1levelsindiabeticwomenwithovarianpolycysticsyndromeandhealthywomen AT javarialatif comparisonofglucagonlikepeptide1levelsindiabeticwomenwithovarianpolycysticsyndromeandhealthywomen AT amirnaveed comparisonofglucagonlikepeptide1levelsindiabeticwomenwithovarianpolycysticsyndromeandhealthywomen AT ayeshayousaf comparisonofglucagonlikepeptide1levelsindiabeticwomenwithovarianpolycysticsyndromeandhealthywomen |