To select the optimal immunohistochemical staining method for pigmented melanoma

Abstract Melanin granules may be difficult to distinguish from the brown reaction product of 3,3’-diaminobenzidine (DAB) in immunostaining. To identify a reliable immunostaining protocol for pigmented melanoma that preserves tissue integrity while enabling clear observation of antigen-antibody bindi...

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Bibliographic Details
Main Authors: Juan Lin, Zhijie You, Xin Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-13085-1
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