Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells

Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells

The pivotal role of metabolic reprogramming in cancer-related drug resistance, through the tryptophan-catabolized kynurenine pathway (KP), has been particularly underscored in recent research. This pathway, driven by indoleamine 2,3-dioxygenase 1 (IDO1), facilitates immune evasion and promotes tumor...

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Bibliographic Details
Main Authors: Irene Kang, George Theodoropoulos, Medhi Wangpaichitr
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
lung cancer
metabolism
immunometabolism
drug resistance
kynurenine
dual inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1524651/full
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