Polysaccharide of Atractylodes macrocephala Koidz alleviate LPS-induced inflammatory liver injury by reducing pyroptosis of macrophage via regulating LncRNA GAS5/miR-223-3p/NLRP3 axis

Polysaccharide of Atractylodes macrocephala Koidz alleviate LPS-induced inflammatory liver injury by reducing pyroptosis of macrophage via regulating LncRNA GAS5/miR-223-3p/NLRP3 axis

IntroductionPyroptosis is a distinctive form of inflammatory cell death, mediated by the activation of the inflammasome, which initiates a potent inflammatory response. Long non-coding RNAs (lncRNAs) modulate pyroptosis by targeting microRNAs and their target genes through a competing endogenous RNA...

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Main Authors: Xiaoxiao Chen, Shuzhan Yang, Xin Long, Wanyan Li, Bingxin Li, Cheng Fu, Caoxue Zhen, Danning Xu, Xinliang Fu, Nan Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
pyroptosis
polysaccharide of Atractylodes macrocephala Koidz
liver inflammation
macrophage
ceRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1593689/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1593689/full

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