3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

Abstract Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health‐promoting and longevity‐extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity. Here, we r...

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Main Authors: Guo Chen, Wei Xie, Jihoon Nah, Allan Sauvat, Peng Liu, Federico Pietrocola, Valentina Sica, Didac Carmona‐Gutierrez, Andreas Zimmermann, Tobias Pendl, Jelena Tadic, Martina Bergmann, Sebastian J Hofer, Lana Domuz, Sylvie Lachkar, Maria Markaki, Nektarios Tavernarakis, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer
Format: Article
Language:English
Published: Springer Nature 2019-10-01
Series:EMBO Molecular Medicine
Subjects:
caloric restriction
caloric restriction mimetic
cardioprotection
TFE3
TFEB
Online Access:https://doi.org/10.15252/emmm.201910469
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https://doi.org/10.15252/emmm.201910469

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