Multiple allostery in the regulation of PDGFR beta kinase activities

Multiple allostery in the regulation of PDGFR beta kinase activities

Platelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase (RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of PDGFRβ is associated with cardiovascular and fibrosis diseases. Thus, its kinase activity needs to be precisely reg...

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Bibliographic Details
Main Authors: Zhang Yanfeng, Wang Meimei, Shao Guangcan, Shang Qingbin, Dong Mengqiu, Qin Xiaohong, Mi Li-Zhi
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
allosteric regulation
symmetric dimerization
kinase insert
platelet-derived growth factor receptor beta (PDGFRβ)
colony stimulating factor 1 receptor (CSF1R)
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024205
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https://www.sciengine.com/doi/10.3724/abbs.2024205

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