Clinical Interaction between Brain and Kidney in Small Vessel Disease
Patients with chronic kidney disease (CKD) are well known to have a higher prevalence of cardiovascular disease from epidemiological studies. Recently, CKD has also been shown to be related to neurological disorders, not only ischemic brain injury but also cognitive impairment. This cerebrorenal c...
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/306189 |
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| author | Masaki Mogi Masatsugu Horiuchi |
| author_facet | Masaki Mogi Masatsugu Horiuchi |
| author_sort | Masaki Mogi |
| collection | DOAJ |
| description | Patients with chronic kidney disease (CKD) are well known to have a higher prevalence of cardiovascular disease from epidemiological studies. Recently, CKD has also been shown to be related to neurological disorders, not only ischemic brain injury but also cognitive impairment. This cerebrorenal connection is considered to involve small vessel disease in both the kidney and brain, based on their hemodynamic similarities. Clinical studies suggest that markers for CKD such as estimated glomerular filtration rate (eGFR), proteinuria, and albuminuria may be helpful to predict brain small vessel disease, white matter lesions (WMLs), silent brain ischemia (SBI), and microhemorrhages. Recently, changes in the vascular system of the brain have been shown to contribute to the onset and progression of cognitive impairment, not only vascular dementia but also Alzheimer's disease. Patients with CKD are also reported to have higher risk of impaired cognitive function in the future compared with non-CKD subjects. These results indicate that CKD markers may be helpful to predict the future risk of neuronal disease. |
| format | Article |
| id | doaj-art-b3022e19a4d44ea9bb01cbc8bada120d |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-b3022e19a4d44ea9bb01cbc8bada120d2025-02-03T06:06:13ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/306189306189Clinical Interaction between Brain and Kidney in Small Vessel DiseaseMasaki Mogi0Masatsugu Horiuchi1Department of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Tohon, Ehime 791-0295, JapanDepartment of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Tohon, Ehime 791-0295, JapanPatients with chronic kidney disease (CKD) are well known to have a higher prevalence of cardiovascular disease from epidemiological studies. Recently, CKD has also been shown to be related to neurological disorders, not only ischemic brain injury but also cognitive impairment. This cerebrorenal connection is considered to involve small vessel disease in both the kidney and brain, based on their hemodynamic similarities. Clinical studies suggest that markers for CKD such as estimated glomerular filtration rate (eGFR), proteinuria, and albuminuria may be helpful to predict brain small vessel disease, white matter lesions (WMLs), silent brain ischemia (SBI), and microhemorrhages. Recently, changes in the vascular system of the brain have been shown to contribute to the onset and progression of cognitive impairment, not only vascular dementia but also Alzheimer's disease. Patients with CKD are also reported to have higher risk of impaired cognitive function in the future compared with non-CKD subjects. These results indicate that CKD markers may be helpful to predict the future risk of neuronal disease.http://dx.doi.org/10.4061/2011/306189 |
| spellingShingle | Masaki Mogi Masatsugu Horiuchi Clinical Interaction between Brain and Kidney in Small Vessel Disease Cardiology Research and Practice |
| title | Clinical Interaction between Brain and Kidney in Small Vessel Disease |
| title_full | Clinical Interaction between Brain and Kidney in Small Vessel Disease |
| title_fullStr | Clinical Interaction between Brain and Kidney in Small Vessel Disease |
| title_full_unstemmed | Clinical Interaction between Brain and Kidney in Small Vessel Disease |
| title_short | Clinical Interaction between Brain and Kidney in Small Vessel Disease |
| title_sort | clinical interaction between brain and kidney in small vessel disease |
| url | http://dx.doi.org/10.4061/2011/306189 |
| work_keys_str_mv | AT masakimogi clinicalinteractionbetweenbrainandkidneyinsmallvesseldisease AT masatsuguhoriuchi clinicalinteractionbetweenbrainandkidneyinsmallvesseldisease |