Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer
Somatic cells can be reprogrammed into a pluripotent cellular state similar to that of embryonic stem cells. Given the significant physiological differences between the somatic and pluripotent cells, cell reprogramming is associated with a profound reorganization of the somatic phenotype at all leve...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/8073721 |
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| _version_ | 1832552875371266048 |
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| author | Javier Prieto Josema Torres |
| author_facet | Javier Prieto Josema Torres |
| author_sort | Javier Prieto |
| collection | DOAJ |
| description | Somatic cells can be reprogrammed into a pluripotent cellular state similar to that of embryonic stem cells. Given the significant physiological differences between the somatic and pluripotent cells, cell reprogramming is associated with a profound reorganization of the somatic phenotype at all levels. The remodeling of mitochondrial morphology is one of these dramatic changes that somatic cells have to undertake during cell reprogramming. Somatic cells transform their tubular and interconnected mitochondrial network to the fragmented and isolated organelles found in pluripotent stem cells early during cell reprogramming. Accordingly, mitochondrial fission, the process whereby the mitochondria divide, plays an important role in the cell reprogramming process. Here, we present an overview of the importance of mitochondrial fission in both cell reprogramming and cellular transformation. |
| format | Article |
| id | doaj-art-b2f0a8935d1a44d6b689291d659c5e1b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b2f0a8935d1a44d6b689291d659c5e1b2025-02-03T05:57:40ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/80737218073721Mitochondrial Dynamics: In Cell Reprogramming as It Is in CancerJavier Prieto0Josema Torres1Departamento Biología Celular, Biología Funcional y Antropología Física, University of Valencia, 46100 Burjassot, SpainDepartamento Biología Celular, Biología Funcional y Antropología Física, University of Valencia, 46100 Burjassot, SpainSomatic cells can be reprogrammed into a pluripotent cellular state similar to that of embryonic stem cells. Given the significant physiological differences between the somatic and pluripotent cells, cell reprogramming is associated with a profound reorganization of the somatic phenotype at all levels. The remodeling of mitochondrial morphology is one of these dramatic changes that somatic cells have to undertake during cell reprogramming. Somatic cells transform their tubular and interconnected mitochondrial network to the fragmented and isolated organelles found in pluripotent stem cells early during cell reprogramming. Accordingly, mitochondrial fission, the process whereby the mitochondria divide, plays an important role in the cell reprogramming process. Here, we present an overview of the importance of mitochondrial fission in both cell reprogramming and cellular transformation.http://dx.doi.org/10.1155/2017/8073721 |
| spellingShingle | Javier Prieto Josema Torres Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer Stem Cells International |
| title | Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer |
| title_full | Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer |
| title_fullStr | Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer |
| title_full_unstemmed | Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer |
| title_short | Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer |
| title_sort | mitochondrial dynamics in cell reprogramming as it is in cancer |
| url | http://dx.doi.org/10.1155/2017/8073721 |
| work_keys_str_mv | AT javierprieto mitochondrialdynamicsincellreprogrammingasitisincancer AT josematorres mitochondrialdynamicsincellreprogrammingasitisincancer |